Sort   by:  
 Page size 
MetabolomicsHuman umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice

BACKGROUND: Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical studies to clinical settings has necessitated the exploration o...

2023-07-25 | MTBLS7759 | MetaboLights
MetabolomicsCombined Mesenchymal Stem Cells and Metformin Therapy Modulates Key Macromolecular Pathways in Pulmonary Fibrosis: Evidence from Untargeted Metabolomics

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. Current treatment options remain limited, driving interest in novel therapeutic approaches. Mesenchymal stem cells (MSCs) possess immunomodulatory and regenerative properties, while metformin, traditionally ...

2025-08-25 | MTBLS12893 | MetaboLights
MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
ProteomicsMesenchymal stem cell integrin-associated complexes
The composition and stiffness of the extracellular matrix (ECM) environment that surrounds Multipotent mesenchymal stem cells (MSCs) stem cells dictates transcriptional programming, thereby affecting stem cell lineage decision-making. Cells sense force between themselves and their microenvironment ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079956 | MassIVE
ProteomicsProteome characterization of mesenchymal stem cells and exosomes
Proteome characterization of mesenchymal stem cells (MSC) and exosomes. MSCs were cultured in normoxic, hypoxic and in presence of FBS. Exosomes were prepared from normoxic and hypoxic conditions.
ORGANISM(S): Homo Sapiens (human) 
2021-04-27 | PXD025584 | JPOST Repository
ProteomicsMulti-omics approach to identify age-related changes in mesenchymal stem cells
Mesenchymal stem cells (MSC) are bone-marrow derived cells, capable of multipotent differentiation into connective tissues including bone, tendon and cartilage. They are an attractive source for autologous cell-based treatments for a range of clinical diseases and injuries. MSCs have been demonstra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079981 | MassIVE
TranscriptomicsIdentity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow (I)
Human bone marrow mesenchymal stem cells (hBM-MSCs) hold promise for treating diseases for which currently no therapeutic options exist. High quantities of MSCs are needed, requiring extensive cell expansion in long-term culture. However, the fundamental biological properties of MSCs can be altered ...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-68926 | biostudies-arrayexpress
TranscriptomicsSurface topography enhances differentiation of mesenchymal stem cells towards osteogenic and adipogenic lineages
Surface topography impacts on cell growth and differentiation, but it is not trivial to generate defined surface structures and to assess the relevance of specific topographic parameters. In this study, we have systematically compared in vitro differentiation of mesenchymal stem cells (MSCs) on a va...
ORGANISM(S): Homo sapiens 
2018-09-20 | E-MTAB-7177 | biostudies-arrayexpress
TranscriptomicsEffects of co-culture of Endothelial Cells with Mesenchymal Stem Cells on Gene Expression
Study designed to explore the effects of endothelial cell/MSC co-culture on individual gene expression profile of each cell type 4 independent samples from each of 4 groups: MSCs cultured alone; Pulmonary endothelial cells cultured alone; MSCs co-cultured with PECs then FACS separated; PECs co-cultu...
ORGANISM(S): Homo sapiens 
2012-09-15 | E-GEOD-40613 | biostudies-arrayexpress
MetabolomicsPreliminary exploration of the ability of HUC-MSCs to restore the lung microbiota and related metabolite disorders in IPF treatment: Combining 16S sequencing and metabolite analysis

Abstract

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive pulmonary disease, and effective therapies to reverse the natural course of IPF are lacking. A growing number of studies have shown that the use of human umbilical cord-derived mesenchymal stem cells (HUC-...

2025-09-01 | MTBLS12922 | MetaboLights
Sort   by:  
 Page size