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MetabolomicsCalenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects via the IRS1/PI3K/AKT signaling pathway in a type 2 diabetes model Calenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects via the IRS1/PI3K/AKT signaling pathway in cell, organ-on-a-chip, and mouse models of type 2 diabetes.

Glibenclamide (GLIB), a type 2 diabetes therapy, has long-term safety concerns. Probiotic–drug coadministration, an emerging adjunctive approach for metabolic diseases, improves therapeutic outcomes and side effects. Here, Bifidobacterium animalis B960 was selected from 71 probiotic strains by HP...

2025-07-08 | MTBLS12697 | MetaboLights
ProteomicsProteomic reveals reasons for acquired drug resistance in lung cancer derived brain metastasis based on a newly established multi-organ microfluidic chip model
Anti-tumor drugs can effectively shrink the lesions of primary lung cancer; however, it has limited therapeutic effect on patients with brain metastasis (BM). A BM preclinical model based on a multi-organ microfluidic chip has been established proficiently in our previous work. In this study, the BM...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021760 | Pride
Lung cancer  brain metastasis  microfluidic organ-on-a-chip  drug resistance  proteomic. 
UnknownTapeTech microfluidic connectors: adhesive tape-enabled solution for organ-on-a-chip system integration.
Not available
S-EPMC11795533 | biostudies-literature
GenomicsModeling of lung-liver interaction during infection in a human fluidic organ-on-a-chip
Modeling of lung-liver interaction during infection in a human fluidic organ-on-a-chip
PRJNA1246642 | ENA
UnknownDevelopment of a flexible 3D printed TPU-PVC microfluidic devices for organ-on-a-chip applications.
Not available
S-EPMC11839916 | biostudies-literature
UnknownIn vitro metabolic activation of vitamin D3 by using a multi-compartment microfluidic liver-kidney organ on chip platform.
Not available
S-EPMC6420623 | biostudies-literature
MetabolomicsSpatiotemporal determination of metabolite activities in the corneal epithelium on a chip
The corneal epithelial barrier maintains the metabolic activities of the ocular surface by regulating membrane transporters and metabolic enzymes responsible for the homeostasis of the eye as well as the pharmacokinetic behavior of drugs. Despite its importance, no established biomimetic in vitro me...
2021-07-13 | MTBLS2274 | MetaboLights
ProteomicsCoupling microdroplet-based sample preparation, multiplexed isobaric labeling, and nanoflow peptide fractionation for deep proteome profiling of tissue microenvironment
Existing spatially-resolved proteomics technologies cannot provide deep proteome coverage due to limited sensitivity and poor sample recovery. Herein, we seamlessly combined laser capture microdissection with a low-volume sample processing technology that includes a microfluidic device named microPO...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-25 | MSV000093925 | MassIVE
UnknownMicrofluidic Chamber Design for Organ-on-a-Chip: A Computational Fluid Dynamics Study of Pillar Geometry and Pulsatile Perfusion.
Not available
S-EPMC12839026 | biostudies-literature
UnknownCompartmentalized organ-on-a-chip structure for spatiotemporal control of oxygen microenvironments.
Not available
S-EPMC9587069 | biostudies-literature
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