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Transcriptomics1,25-dihydroxyvitamin D3-induced genes in mouse mixed neuron-glial cell cultures
Transcriptomic response of mouse mixed neuron-glial cell cultures to 1,25-dihydroxyvitamin D3 6 samples are analysed with three biological replicates in two conditions, control versus 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)
ORGANISM(S): Mus musculus 
2013-03-25 | E-GEOD-41184 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of mixed glial cultures grown on different growth surfaces
Biomechanical alterations of the extracellular matrix (ECM) and injury-induced or disease-induced cell loss are major contributors to pathological astrocyte activation (astrogliosis) in the CNS and the formation of glial scars. This in vitro experiment is intended to identify transcriptional alterat...
ORGANISM(S): Mus musculus 
2026-06-29 | E-MTAB-17287 | biostudies-arrayexpress
ProteomicsImipramine affects the expression of proteins involved in oxidative stress and immunity in rat primary glial cell culture
Glial cells (microglia and astrocytes) have recently became appreciated as an important target for antidepressant drugs. Here we report on the results of comprehensive proteomic analysis of the alteration in protein profile of rat primary mixed glial culture exposed to imipramine. Two-dimensional di...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-05-17 | PXD007977 | Pride
Imipramine  mixed glial cell culture  microglia  proteome  2d-dige 
TranscriptomicsTranscription profiling of activated mixed glial (microglia) and monocyte-derived macrophages
Since macrophage activation can now be studied at a global level using modern microarray and proteomic analyses, discovery of novel macrophage activation genes is inevitable and important for understanding HIV-associated dementia (HAD). We isolated two different types of primary human macrophages, m...
ORGANISM(S): Homo sapiens 
2007-08-29 | E-GEOD-1910 | biostudies-arrayexpress
TranscriptomicsClonal Immortalized Human Glial Cell Lines Support Varying Levels of JC Virus Infection due to Differences in Cellular Gene Expression
JC virus (JCV) is a ubiquitous human polyomavirus that causes the demyelinating disease Progressive Multifocal Leukoencephalopathy (PML). JCV replicates in limited cell types in culture, predominantly in human glial cells. Thus, productive JCV infection is an indicator of the host cell transcription...
ORGANISM(S): Homo sapiens 
2013-10-17 | E-GEOD-45639 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat CNS mixed glial cultures treated with cytokines
To examine changes in gene expression that might occur in CNS glial cells in response to the secreted products of immune cells, we used gene array analysis to assess the early effects of different cytokine mixtures on rat mixed CNS glia in culture. We compared effects at 6 hours of cytokines typical...
ORGANISM(S): Rattus norvegicus 
2008-11-15 | E-GEOD-9659 | biostudies-arrayexpress
TranscriptomicsmiRNA analysis of HBMVECs exposed or unexposed to U87 glioma cells
A key step in angiogenesis is the upregulation of growth factor receptors on endothelial cells. Here we demonstrate that a small regulatory microRNA, miR-296 has a major role in this process. Glioma cells and angiogenic growth factors elevate the level of miR-296 in primary human brain microvascular...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-13091 | biostudies-arrayexpress
TranscriptomicsCulture induced changes in Blood-Brain Barrier transcriptome: implications for amino acid transporters in vivo
Tight homeostatic control of brain amino acids (AA) depends on transport via solute family carrier proteins expressed by the Blood-Brain Barrier (BBB) microvascular endothelial cells (BMEC). To characterize the mouse BMEC transcriptome and probe culture-induced changes microarray analyses of PECAM-1...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-14375 | biostudies-arrayexpress
TranscriptomicsCorticosteroid treatment of glial cell types
Primary mixed glial cultures were prepared from dissociated cerebral cortices of Sprague-Dawley rats at postnatal day 1 to 3 and glial populations were isolated by sequential rotary shaking procedures using well-established protocols. Cultured cells were exposed to 1 micromol dexamethasone for 24hou...
ORGANISM(S): Rattus norvegicus 
2014-03-08 | E-MTAB-1695 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human rimary human neuronal and glial cell cultures response to estrogen treatment
The purpose of this experiment was to identify oestrogen regulated genes in human primary cell cultures of neuronal and glial cells modelling the developing human nervous system. We were especially interested in genes involved in proliferation, differentiation and migration of neuronal cells and gen...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-10097 | biostudies-arrayexpress
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