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ProteomicsInvestigating the effect of molecular crowding agents on protein stability in a bacterial proteome
Molecular crowding refers to the restriction of space available for molecular mobility in solution due to the presence of other macromolecules. Crowding can influence biological phenomena such as protein stability and folding, diffusion, enzyme kinetics, molecular interactions, and phase separation....
ORGANISM(S): Bacteria Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) 
2026-02-23 | PXD067043 | Pride
Thermal proteomics  cupriavidus necator  macromolecular crowding 
ProteomicsCompetitive Binding and Molecular Crowding Regulate the Cytoplasmic Interactome of Non-Viral Polymeric Gene Delivery Vectors
In contrast to the processes controlling the complexation, targeting and uptake of polycationic gene delivery vectors, the molecular mechanisms regulating their cytoplasmic dissociation remains poorly understood. Upon cytosolic entry, vectors become exposed to a complex, concentrated mixture of mole...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028512 | Pride
Gene delivery Rna delivery Polymer brush Proteomics Cytosolic interactome Polycationic vector Lc-ms/ms 
UnknownMolecular crowding accelerates ribozyme docking and catalysis.
Not available
S-EPMC4277754 | biostudies-literature
ProteomicsExcess protein synthesis, denatured proteins or molecular crowding spontaneously induce HSF1 trimerisation and activation
Stress responses are a key feature of normal physiology and are usurped by cancer cells to ensure enhanced protein synthesis for growth, to compensate for genomic instability, and to protect cancer cells from therapy induced stress. Heat shock factor-1 (HSF1) is a major stress-response transcription...
ORGANISM(S): Homo sapiens (Human) 
2024-08-14 | PXD037662 | Pride
Lc-msms Hsf1 Stress Hsp70 Hsp90 Crowding Hdx-ms Protein folding 
UnknownMolecular Crowding Facilitates Ribozyme-Catalyzed RNA Assembly.
Not available
S-EPMC10451029 | biostudies-literature
GenomicsMicroarray-predicted marker genes and molecular pathways indicating combined crowding and thermal stress in rainbow trout (Oncorhynchus mykiss)
Microarray-predicted marker genes and molecular pathways indicating combined crowding and thermal stress in rainbow trout (Oncorhynchus mykiss)
PRJNA530704 | ENA
UnknownRegulation of DNA nucleases by molecular crowding.
Not available
S-EPMC1919490 | biostudies-literature
UnknownMolecular Crowding Suppresses Mechanical Stress-Driven DNA Strand Separation.
Not available
S-EPMC11661227 | biostudies-literature
TranscriptomicsSweet corn: low- vs. high-yielding hybrids
Transcriptional profiling of sweet corn plant density (crowding stress) tolerance influencing yield. Tolerance to crowding stress has played a crucial role in improving agronomic productivity in field corn; however, commercial sweet corn hybrids vary greatly in crowding stress tolerance. The experim...
ORGANISM(S): Zea mays 
2016-01-05 | E-GEOD-73435 | biostudies-arrayexpress
UnknownMolecular Crowding and Diffusion-Capture in Synapses.
Not available
S-EPMC7399191 | biostudies-literature
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