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MetabolomicsMetabolomic comparison of RA vs healthy monocytes undergoing different ex vivo activation conditions

Rheumatoid arthritis (RA) monocytes are primed for inflammatory activation, but their disease-intrinsic molecular features have not been systematically profiled across omics layers. We aimed to define RA-associated alterations in primary human monocytes using an integrated multi-omics approach un...

2026-10-16 | MTBLS14227 | MetaboLights
MetabolomicsMetabolomics analysis of RA vs healthy monocytes immediately following CD14+ MACS isolation

Rheumatoid arthritis (RA) monocytes are primed for inflammatory activation, but their disease-intrinsic molecular features have not been systematically profiled across omics layers. We aimed to define RA-associated alterations in primary human monocytes using an integrated multi-omics approach un...

2026-10-16 | MTBLS14228 | MetaboLights
TranscriptomicsTranscription profiling of human peripheral blood monocytes after constitutive adhesion to naive human umbilical vein endothelial cells (HUVEC) to investigate changes in gene expression patterns
Investigation of the alterations in the gene expression pattern of peripheral blood monocytes after constitutive adhesion to naive human umbilical vein endothelial cells
ORGANISM(S): Homo sapiens 
2007-03-10 | E-MEXP-854 | biostudies-arrayexpress
ProteomicsProteome characterization of synovial fluid polarized healthy monocytes
This project involves proteome characterization of healthy monocytes polarized (activated) with synovial fluid (SF) versus serum from patients with juvenile idiopathic arthritis (JIA). The objective is to investigate the influence of SF on monocytes at the proteome level, using serum polarized monoc...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD033983 | Pride
Monocytes Inflammation Juvenile idiopathic arthritis Synovial fluid 
ProteomicsImmune Complex-Induced Migration of Slan+ Non-Classical Monocytes
Slan+ Non-Classical Monocytes migrate on immobilized immune complexes. This phenomenon can be blcoked with anti-CD16 blocking antibodies and is therefore thought to be mediated via CD16 (FcyRIII). Nonetheless, other CD16+ cells, such as NK cells or neutrophils, as well as lineage related cells suchs...
ORGANISM(S): Homo sapiens (Human) 
2026-07-09 | PXD079927 | Pride
Slanmo Cd16a Immune complexes Fcyriiia Migration Slan+ non-classical monocytes Haptokinesis 
Transcriptomicsstroma+monocytes
Gene expression of adherent cells in a coculture of the human bone marrow stromal cell line HS-27a and peripheral blood monocytes (CD14+ cells) was compared to HS-27a cultured alone. Microarray experiments were conducted using CD14+ cells from 7 healthy donors over a period of >7 months. Monocytes ...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-831 | biostudies-arrayexpress
TranscriptomicsLong non-coding RNA landscape in human monocytes
We report the lncRNAs transcribed in the human primary monocyte cells. We performed deep RNA sequencing from four healthy individuals. In addition, the raw RNA-Seq data from 11 human monocyte samples were selected from public databases and generated a total ~1.7 billion reads. We identified ~ 8,000 ...
ORGANISM(S): Homo sapiens 
2016-02-19 | E-GEOD-69753 | biostudies-arrayexpress
ProteomicsCOMPARATIVE ANALYSIS OF THE PROTEOME OF KUPFFER CELLS AND MONOCYTES
Macrophage population in most mammalian organs consists of cells of different origin, with the exception of the central nervous system and the liver, where macrophages of monocytic origin are almost completely absent. The reasons for such distribution and the phenomenon of coexistence of the two sep...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD018586 | Pride
Kuppfer cells Macrophages Monocytes 
ProteomicsProteomic analysis of human monocytes in atherosclerosis related and non-related to chronic kidney disease
We performed quantitative and qualitative proteomic analysis by nano LC-MS/MS to investigate global changes in the proteome of monocytes isolated from patients' peripheral blood by immunomagnetic separation. Cells were isolated from patients at different stages of non-related and chronic kidney dise...
ORGANISM(S): Homo sapiens (Human) 
2024-01-23 | PXD041367 | Pride
Human Monocytes Atherosclerosis Chronic kidney disease Lc-ms/ms 
TranscriptomicsTranscription profiling of human HCMV-Infected monocytes
Human cytomegalovirus induces a pro-inflammatory monocyte following infection and we have evidence that NF-κB and phosphatidylinositol 3-kinase [PI(3)K] are key mediators in this early activation. To begin to address how these signalling pathways are responsible for the rapid activation of infecte...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9601 | biostudies-arrayexpress
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