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TranscriptomicsGene expression analysis in proximal and distal colons of Lcn2-/- IL10-/- double knock-out mice.
Lcn2 is involved in host defense against pathogens, but the function in intestinal mucosal immunity and inflammation remains largely unknown. Genetic ablation of Lcn2 results in early-onset colitis and spontaneous emergence of right-sided colonic tumors in the setting of IL-10 deficiency (Lcn2-/-;IL...
ORGANISM(S): Mus musculus 
2016-03-30 | E-MTAB-4583 | biostudies-arrayexpress
ProteomicsDevelopment of a Global Metabo-Lipid-Prote-omics Method to Compare Healthy Distal and Proximal Colon Biopsies of Mice
This research focuses on understanding the molecular and protein structures of mouse proximal and distal colons (PC/DC) by developing of an integrated multi-omics approach.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-11-02 | MSV000093241 | MassIVE
ProteomicsDevelopment of a Global Metabo-Lipid-Prote-omics Workflow to Compare Healthy Proximal and Distal Colonic Epithelium in Mice
A multimetabo-lipid-prote-omics workflow was developed to characterize the molecular interplay within proximal (PC) and distal (DC) colonic epithelium of healthy mice. This multiomics data set lays the foundation to better understand the two tissue types and can be used to study, for example, colon-...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-04 | PXD046811 | Pride
Metabo-lipid-proteomics  methyl tert-butyl ether  mouse proximal and distal colons  multi-omics 
TranscriptomicsTranscription profiling of mouse HNF4 null mutant colon vs. control colons
Background and Aims: HNF4? is a nuclear hormone receptor transcription factor that has been shown to be required for hepatocyte differentiation and development of the liver. It has also been implicated in regulating expression of genes that act in the epithelium of the lower gastrointestinal tract....
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3116 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profile of colon from wild-type and AE2-knockout mice.
The objective of this study was to identify changes in gene expression levels between wild-type and AE2-knockout colon. 7 wild-type and 7 AE2-null colon RNA samples were compared to identify genes that are differentially expressed in the colon of AE2 knockout mice. Total RNA was collected from both ...
ORGANISM(S): Mus musculus 
2010-04-11 | E-GEOD-19075 | biostudies-arrayexpress
ProteomicsLoss of colonic primary cilia promotes inflammation and carcinogenesis
Primary cilia (PC) are important signaling hubs in cells and we explored their role in colorectal cancer (CRC) and colitis. In the colon we found PC to be mostly present on different subtypes of fibroblasts and exposure of mice to either chemically induced colitis-associated colon carcinogenesis (CA...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-29 | PXD033440 | Pride
Colon carcinogenesis Inflammation Primary cilia Colonic fibroblasts Colitis 
TranscriptomicsGene expression study identifies important protective pathways utilized by appendicitis and appendectomy for ameliorating colitis
BACKGROUND: Appendicitis followed by appendectomy (AA) at a young age protects against later inflammatory bowel disease (IBD). Using a novel murine appendicitis model we earlier demonstrated that AA proffered significant protection against subsequent experimental colitis. AIM: To delineate genes and...
ORGANISM(S): Mus musculus 
2010-09-01 | E-GEOD-23914 | biostudies-arrayexpress
TranscriptomicsRunx1 is a tumor suppressor gene in the mouse gastrointestinal tract
The Runx1 transcription factor plays an important role in tissue homeostasis through its effects on stem/progenitor cell populations and differentiation. The effect of Runx1 on epithelial differentiation of the secretory cell lineage of the colon was recently demonstrated. This study aimed to examin...
ORGANISM(S): Mus musculus 
2012-09-13 | E-GEOD-34292 | biostudies-arrayexpress
UnknownReducing dextran sodium sulfate interference with gene expression quantification in a mouse model of colitis.
Not available
S-EPMC12288034 | biostudies-literature
TranscriptomicsInsights into ulcerative colitis and ileal pouchitis from a model of stasis-induced enteric dysbiosis and genetic susceptibility
Gut dysbiosis and host genetics are implicated as causative factors in inflammatory bowel disease, yet mechanistic insights are lacking. Longitudinal analysis of ulcerative colitis patients following total colectomy with ileal anal anastomosis (IPAA) where >50% develop pouchitis, offers a unique set...
ORGANISM(S): Mus musculus 
2015-09-20 | E-GEOD-71997 | biostudies-arrayexpress
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