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MetabolomicsCD36 palmitoylation regulates the lipid metabolic homeostasis

Alterations in myocardial energy substrate metabolism following myocardial infarction (MI) results in structural and functional abnormalities of the heart. The fatty acid translocase CD36 (CD36), acrucial membrane protein, plays a pivotal role in regulating fatty acid (FA) uptake and lipid homeos...

2025-06-15 | MTBLS12600 | MetaboLights
MetabolomicsCoupling Inflammatory Resolution to Osteogenesis: Lymphatic Vessels as Stage-specific Niche Regulators in Skeletal Healing

Skeletal healing requires the coordinated resolution of inflammation and precise lineage commitment of mesenchymal progenitors, yet the mechanisms coupling these processes remain incompletely defined. Here, we reveal that lymphatic vessels in bone serve as dynamic orchestrato...

2026-01-17 | MTBLS13645 | MetaboLights
ProteomicsEnrichment of Cysteine S-palmitoylated peptides using Sodium Deoxycholate Acid Precipitation - SDC-ACE
S-palmitoylation is a poorly understood post-translational modification that is gaining more attention as an essential regulator of cellular processes. The reversible nature of S-palmitoylation allows for fine-tuned control of cellular events and adaptation to stimuli. The enrichment of S-palmitoyla...
ORGANISM(S): Mus musculus (Mouse) Acyrthosiphon pisum (Pea aphid) 
2026-02-16 | PXD054682 | Pride
Cysteine palmitoylation  mouse brain palmitoylome  dbdb mice  mouse tissue specific palmitoylation 
ProteomicsPalmitoylation couples insulin hypersecretion with β-cell failure in diabetes
Hyperinsulinemia often precedes type 2 diabetes but its role in disease progression is unknown. Palmitoylation, a protein modification implicated in regulated exocytosis, is reversed by acyl-protein thioesterase 1 (APT1). We found altered APT1 biology in pancreatic islets from humans with type 2 dia...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-05 | PXD038554 | Pride
Proteomics Palmitoylation Pancreatic islet Insulin Diabetes 
ProteomicsMouse Liver S-Palmitoylation ZDHHC13 LC-MS/MS
Protein S-palmitoylation is a reversible post-translational modification which adding 16-carbon palmitate to specific cysteines and contributes to variable biological functions such as protein trafficking, scaffolding and signaling. ZDHHC13 is one of the members of DHHC-containing palmitoyl-acyltran...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-29 | PXD003039 | Pride
Zdhhc13 Mouse S-palmitoylation Liver Lc-ms/ms 
ProteomicsAttenuated palmitoylation of serotonin receptor 5-HT1A in brain affects receptor functions and triggers depressive symptoms
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are critically implicated in major depressive disorder (MDD), although underlying mechanisms remain enigmatic. Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains and identified ZDHHC21 as a major pa...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-16 | PXD012736 | Pride
Suicide Depression Mirna Zdhhc Palmitoylation Serotonin 5-ht1a receptor 
ProteomicsApplication of liquid-liquid extraction for N-terminal myristoylation proteomics
Proteins can be modified by lipids in various ways, for example by myristoylation, palmitoylation, farnesylation, and geranylgeranylation—these processes are collectively referred to as lipidation. Current chemical proteomics using alkyne lipids has enabled the identification of lipidated protein ca...
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2023-11-09 | PXD041499 | JPOST Repository
GenomicsRac1 palmitoylation is required for cardiac stress adaptation and regulation of Protein Kinase A signaling
Rac1 palmitoylation is required for cardiac stress adaptation and regulation of Protein Kinase A signaling
PRJNA1306016 | ENA
UnknownCLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation.
Not available
S-EPMC11337767 | biostudies-literature
ProteomicsCysteine S-acetylation is a post-translational modification involved in metabolic regulation
Cysteine is a reactive amino acid central to the catalytic activities of many enzymes and a common target of post-translational modifications (PTMs). Long-chain acyl PTMs, such as palmitoylation, can modify cysteine residues and induce changes in protein subcellular localization. We hypothesized tha...
ORGANISM(S): Mus Musculus (mouse) 
2024-05-29 | PXD052367 | JPOST Repository
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