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TranscriptomicsGenomic mapping of Six1 binding sites during skeletal myoblast differentiation
In this study, the C2C12 cell line, a model used to study myogenesis and regeneration, was allowed to differentiate from myoblast precursor cells to myotubes. Cells were harvested at 3 different timepoints to perform ChIP-on-Chip of Six1, which is a key muscle regulator. We identified global loci bo...
ORGANISM(S): Mus musculus 
2010-07-05 | E-GEOD-20150 | biostudies-arrayexpress
TranscriptomicsWnt signaling involved in mouse myoblast differentiation
Wnt/M-NM-2-catenin signaling is involved in various aspects of skeletal muscle development and regeneration. In addition, Wnt3a and M-NM-2-catenin are required for muscle-specific gene transcription in embryonic carcinoma cells and satellite-cell proliferation during adult skeletal muscle regenerati...
ORGANISM(S): Mus musculus 
2011-07-15 | E-GEOD-30077 | biostudies-arrayexpress
ProteomicsMachine learning inference of continuous single-cell state transitions during myoblast differentiation and fusion
Cells dynamically change their internal organization via continuous cell state transitions to mediate a plethora of physiological processes. Understanding such continuous processes is severely limited due to a lack of tools to measure the holistic physiological state of single cells undergoing a tra...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD047198 | Pride
Machine learning Differentiation Myoblast 
ProteomicsMouse myoblast fusion - Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190
The p38 MAP kinases play critical roles in skeletal muscle biology, but the specific processes that they regulate remain poorly defined. Here we find that activity of p38α/β is important not only for early phases of myoblast differentiation, but also in later stages of myocyte fusion and myofibrill...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD002413 | Pride
Mouse Myoblast Differentiation Fusion 
ProteomicsIdentification of proteolytic events during C2C12 myoblast differentiation
Identification of product of proteolysis during C2C12 myoblast differentiation using subtiligase N-terminomics. Different cell populations collected during a time-course of differentiation (4 days) were used for N-terminal labeling in a forward degradomics approach (n=2). Day0 population= Myoblasts,...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-05-01 | MSV000094657 | MassIVE
ProteomicsProtein synthesis during myoblast differentiation
Mole (MSR) and fractional (FSR) synthesis rates of proteins during C2C12 myoblast differentiation were investigated. Myoblast cultures supplemented with D2O during 0-24 h or 72-96 h of differentiation were analysed by LC-MS/MS to calculate protein FSR and MSR after samples were spiked with yeast alc...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-22 | PXD021125 | Pride
C2c12  muscle  fractional synthesis rate 
TranscriptomicsTranscription profiling of mouse strain C2C12 mRNAs and noncoding RNAs during myoblast differentiation
This experiment compared the expression of mRNAs and noncoding RNAs during myoblast differentiation. The primary aim of the experiment was to identify ncRNAs that were differentially expressed during myotube formation.
ORGANISM(S): Mus musculus 
2008-12-01 | E-TABM-575 | biostudies-arrayexpress
ProteomicsCancer Cell-Derived Small Extracellular Vesicles Impair C2C12 Myoblast Differentiation in the Context of Cancer Cachexia
Cancer cachexia is a complex metabolic syndrome characterized by progressive skeletal muscle wasting and poor clinical outcomes. Previous studies have mainly focused on the association between cancer-derived extracellular vesicles and atrophy of differentiated myotubes, whereas their effects on myob...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-21 | PXD082913 | Pride
Cancer cachexia  small extracellular vesicles  myoblast differentiation  myogenic regulatory factors  myosin heavy chain 
TranscriptomicsA Long Non-coding RNA, LncMyoD, Regulates Skeletal Muscle Differentiation by Blocking IMP2-mediated mRNA Translation
Increasing evidence suggests that Long non-coding RNAs (LncRNAs) represent a new class of regulators of stem cells. However, the roles of LncRNAs in stem cell maintenance and myogenesis remain largely unexamined. For this study, hundreds of novel intergenic LncRNAs were identified that are expresse...
ORGANISM(S): Mus musculus 
2015-08-11 | E-GEOD-68842 | biostudies-arrayexpress
GenomicsCircadian phase-dependent myoblast differentiation and muscle regeneration
Circadian phase-dependent myoblast differentiation and muscle regeneration
PRJNA633579 | ENA
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