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TranscriptomicsTranscription profiling of rat pancreatic beta-cells in response to cytokine exposure and NF-kappa B activation blocking
Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic beta-cells. Based on findings suggesting NF-kappa B plays a role in beta cell apoptosis, we blocked NF-kappa B activation in cytokine-exposed FACS sorted beta cells by a recombinant adenovirus (AdI kappa B((SA)2)) containi...
ORGANISM(S): Rattus norvegicus 
2006-06-16 | E-CBIL-9 | biostudies-arrayexpress
TranscriptomicsIdentification of LMX1B target genes in a tet-off inducible HeLa cell line and in the mouse kidney
LMX1B is a LIM-homeodomain transcription factor essential for development. Putative LMX1B target genes have been identified through mouse gene targeting studies; however, in the absence of in vivo molecular characterization of their regulation, their identity as direct LMX1B targets remains hypothet...
ORGANISM(S): Homo sapiens 
2008-12-03 | E-GEOD-12008 | biostudies-arrayexpress
ModelsSharp2013 - Lipopolysaccharide induced NFkB activation
Markus W. Covert, Thomas H. Leung, Jahlionais E. Gaston & David Baltimore. Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 309, 5742 (2005). Preterm birth is the single biggest cause of significant neonatal morbidity and mortality, and the incidence is rising. Develo...
2024-09-02 | BIOMD0000000489 | BioModels
TranscriptomicsTranscription profiling of bone marrow derived cells from mice stimulated with RANKL to generate osteoclasts in a time series
Bone marrow derived cells stimulated with RANKL (receptor activator of nuclear factor kappa B ligand, also known as Tumor necrosis factor ligand superfamily member 11) to generate osteoclasts.
ORGANISM(S): Mus musculus 
2007-06-06 | E-TABM-212 | biostudies-arrayexpress
GenomicsSuperoxide dismutase-3 downmodulates laminin α5 expression in endothelial cells via Nuclear Factor kappa B signaling inhibition
Superoxide dismutase-3 downmodulates laminin α5 expression in endothelial cells via Nuclear Factor kappa B signaling inhibition
PRJNA782194 | ENA
TranscriptomicsThe RANK/RANKL axis controls vascular dynamics in the bone marrow
Receptor activator of nuclear factor kappa B ligand (RANKL) is an essential cytokine that induces osteoclastic differentiation by monocyte-macrophage lineage precursors. Here, we showed that in addition to its conventional action, RANKL controls vascular permeability in the bone marrow, where it fac...
ORGANISM(S): Mus musculus 
2025-10-23 | E-MTAB-15929 | biostudies-arrayexpress
TranscriptomicsGlobal changes in the nuclear positioning of chromatin domains and genomic interactions that orchestrate B cell fate
The genome is folded into domains that are located in either transcriptionally inert or permissive compartments. Here we used genome-wide strategies to characterize domains during B cell development. Structured Interaction Matrix Analysis revealed that CTCF occupancy was primarily associated with i...
ORGANISM(S): Mus musculus 
2012-10-09 | E-GEOD-40173 | biostudies-arrayexpress
Genomics
CRISPR screen for genes involved in nuclear factor kappa B signaling activation by flagellin
PRJNA798272 | ENA
OtherProteomic study of different culture medium serum volume fractions on RANKL-dependent RAW264.7 cells differentiating into osteoclasts.
Data from ProteomeXchange, PXD ID: PXD001935. File: folder summary. Published as part of Proteome Sci. 2015 May 2;13:16 . From the Abstract: {{i}} ... we compared the capacity for osteoclastogenesis and bone resorption of RANKL-induced RAW 264.7 cells cultured in medium supplemented with 10% FBS an...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320015410 | GPMDB
Resource Reanalysis 
UnknownTumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in Sepsis.
Not available
S-EPMC5820445 | biostudies-literature
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