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ProteomicsProteomic Adaptions in the Spinal Cord of a Breast Cancer Model of Paclitaxel-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating, often dose-limiting, side effect of taxane-based chemotherapy, a cornerstone of breast cancer treatment. Despite its prevalence, no FDA-approved therapies exist for the prevention or treatment of CIPN, underscoring the need for mec...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-13 | PXD074140 | Pride
Chemotherapy-induced peripheral neuropathy  paclitaxel-induced peripheral neuropathy  paclitaxel  breast cancer  proteomics  spinal cord 
ProteomicsTime-resolved multi-omic analysis of paclitaxel exposure in human iPSC-derived sensory neurons unveils mechanisms of chemotherapy-induced peripheral neuropathy
The microtubule-stabilizing drug paclitaxel remains standard of care for various solid malignancies but frequently leads to chemotherapy-induced peripheral neuropathy (CIPN). CIPN is a leading cause for premature treatment termination and a significantly reduced quality of life in long-term cancer s...
ORGANISM(S): Homo sapiens (Human) 
2026-02-22 | PXD070094 | Pride
Chemotherapy-induced peripheral neuropathy Neuroinflammation Pain Tmt Human Induced pluripotent stem cell-derived sensory neurons Paclitaxel Neurodegeneration 
GenomicsLongitudinal RNA sequencing of skin and DRG neurons in mice with paclitaxel-induced peripheral neuropathy
Longitudinal RNA sequencing of skin and DRG neurons in mice with paclitaxel-induced peripheral neuropathy
PRJNA767618 | ENA
ProteomicsA human iPSC-derived sensory neuron platform for high-throughput discovery of neuroprotectants against chemotherapy-induced peripheral neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting side effect of cancer treatment, yet the lack of predictive human models has hindered therapeutic progress. We have established a scalable model of paclitaxel-induced axon degeneration and neurotoxicity in iPSC-derived sensor...
ORGANISM(S): Homo sapiens (Human) 
2026-04-03 | PXD074954 | Pride
Axon degeneration Ipsc-derived sensory neurons Ste20 kinases Neuroprotective small molecules High-throughput screening Chemotherapy-induced peripheral neuropathy 
UnknownPINK1 alleviates thermal hypersensitivity in a paclitaxel-induced Drosophila model of peripheral neuropathy.
Not available
S-EPMC7498067 | biostudies-literature
UnknownPharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.
Not available
S-EPMC4592389 | biostudies-literature
TranscriptomicsLongitudinal RNA sequencing of skin and DRG neurons in mice with paclitaxel-induced peripheral neuropathy
Paclitaxel-induced peripheral neuropathy is a significant problem, which afflicts up to 70% of chemotherapy patients. Therapeutic interventions are currently unavailable due to an incomplete understanding of the underlying mechanisms. We previously discovered a major target in the skin, MMP-13, whic...
ORGANISM(S): Mus musculus 
2021-10-12 | GSE185084 | GEO
UnknownPrevention of paclitaxel-induced peripheral neuropathy by lithium pretreatment.
Not available
S-EPMC3475250 | biostudies-literature
UnknownTargeting Peroxisome Proliferator-Activated Receptor-α (PPAR- α) to reduce paclitaxel-induced peripheral neuropathy.
Not available
S-EPMC8226373 | biostudies-literature
UnknownLongitudinal RNA Sequencing of Skin and DRG Neurons in Mice with Paclitaxel-Induced Peripheral Neuropathy.
Not available
S-EPMC9564132 | biostudies-literature
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