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TranscriptomicsDifferential IFNa-stimulated gene expression profiles in PLZF-inducible U937T monocyte cells
Sensitivity to Interferon (IFN) is determined by a complex coordination of genetic and environmental factors. A previous experiment using two renal cancer cell lines differing markedly in their response to IFN were analyzed for their ISG profiles in order to determine gene expression changes associa...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-16196 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human patients with t(11;17) or t(7;17) translocations and with the RARA-PLZF status known were analysed for changes in expression related to the reciprocal status
This study supports an active role for PLZF and RARα-PLZF in leukemogenesis, identifies upregulation of CRABPI as a novel mechanism contributing to retinoid resistance and reveals the ability of the reciprocal fusion gene products to mediate distinct; epigenetic effects contributing to the leukemic...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8510 | biostudies-arrayexpress
TranscriptomicsDownregulation of Plzf gene ameliorates metabolic and cardiac traits in the spontaneously hypertensive rat.
The spontaneously hypertensive rat (SHR) is the most widely used model of essential hypertension and is predisposed to left ventricular hypertrophy, myocardial fibrosis, and metabolic disturbances. Recently, a quantitative trait locus (QTL) influencing blood pressure, left ventricular mass and heart...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-MTAB-3831 | biostudies-arrayexpress
ProteomicsProteomics analysis of physiological effect of ZBTB16 (PLZF) on osteogenic differentiation of human valve interstitial cells (VICs) by DDA PASEF on TimsToF Pro
During fundamental proteotranscriptomic analysis of human valve interstitial cells (VICs) osteogenic differentiation, we revealed ZBTB16 (PLZF) as one of the most upregulated proteins. Thus, to investigate its physiological role in VICs osteogenic differentiation we performed its overexpression by l...
ORGANISM(S): Homo sapiens (Human) 
2022-10-21 | PXD031572 | Pride
Zbtb16  plzf  osteogenic differentiation  valve interstitial cells  pasef  timstof pro 
TranscriptomicsExpression data comparing PLZF+/+, PLZF +/lu, PLZF lu/lu gammadelta NKT cells
Natural killer (NKT) T cells exhibit tissue distribution, surface phenotype, and functional responses that are strikingly different from those of conventional T cells. The transcription factor PLZF is responsible for most of these properties, as its ectopic expression in conventional T cells is suff...
ORGANISM(S): Mus musculus 
2012-11-09 | E-GEOD-42168 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human U937T:PLZF-RARa Inducible Cells
The PLZF-RARa fusion oncoprotein is overexpressed in the t(11;17) subtype of acute promyelocytic leukemia. Gene expression microarrays were used to identify genes involved in leukemic transformation. We used microarray to detect gene expression changes induced by the PLZF-RARa fusion oncoprotein in ...
ORGANISM(S): Homo sapiens 
2009-12-05 | E-GEOD-18476 | biostudies-arrayexpress
TranscriptomicsPLZF expression maps the early stages of ILC1 lineage development
Diverse populations of natural killer cells, which exert critical early cytolytic functions against virally infected cells, have recently been uncovered, raising issues of lineage relationships. We used expression of the transcription factor PLZF to identify the developmental intermediates of ILC1s,...
ORGANISM(S): Mus musculus 
2015-02-13 | E-GEOD-65898 | biostudies-arrayexpress
ProteomicsPLZF and DDX5 interacting proteins in spermatogonia
DDX5, or PLZF co-immunoprecipitation in lysates from cultured undifferentiated spermatogonia followed by identification of eluted proteins using mass spectrometry. IgG control IPs included.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-02-24 | MSV000083476 | MassIVE
GenomicsPLZF acetylation levels regulate NKT cell diffrentiation
PLZF acetylation levels regulate NKT cell diffrentiation
PRJNA528095 | ENA
GenomicsPLZF acetylation levels regulate NKT cell differentiation
PLZF acetylation levels regulate NKT cell differentiation
PRJNA721614 | ENA
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