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ProteomicsA GABARAP−PtdIns3K-C1 positive feedback loop at the heart of the phagophore nucleation
Macroautophagy/autophagy is a cellular process allowing the degradation of intracellular components during starvation. In mammalian cells, autophagosomes can reach over 1000 nm within 30 min after triggering starvation, but how such substantial amounts of membranes can be synthesized within a brief ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-02 | PXD074963 | Pride
Autophagy  cryo-em  gabarap  hdx-ms  lc3  positive feedback loop  xl-ms 
ProteomicsA positive feedback loop controls Toxoplasma chronic differentiation
Successful infection strategies must balance pathogen amplification and persistence. In Toxoplasma gondii, this is accomplished through differentiation into dedicated cyst-forming chronic stages that avoid clearance by the host immune system. The transcription factor BFD1 is both necessary and suffi...
ORGANISM(S): Toxoplasma gondii ME49 
2023-08-07 | PXD039648 | Pride
T. gondii Lc-msms Parasite development Gene expression 
GenomicsZNF252P promotes tumorigenesis by activating c-Myc-mediated positive feedback loop
ZNF252P promotes tumorigenesis by activating c-Myc-mediated positive feedback loop
PRJNA1132162 | ENA
ProteomicsA GABARAP−PtdIns3K-C1 positive feedback loop at the heart of the phagophore nucleation
Macroautophagy/autophagy is a cellular process enabling degradation of intracellular components during starvation. In mammalian cells, autophagosomes can reach diameters of over 1000 nm within 30 min after triggering starvation, but how such substantial amounts of membranes can be synthesized within...
ORGANISM(S): Homo sapiens (Human) 
2026-07-02 | PXD079187 | Pride
Structural characterization Pi3k Xl-ms Cryo-em Hdx-ms Autophagy 
ProteomicsA positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signaling in Toxoplasma gondii.
Fundamental processes of obligate intracellular parasites, such as Plasmodium falciparum and Toxoplasma gondii are controlled by a set of plant-like calcium dependent kinases (CDPKs), the conserved cAMP- and cGMP-dependent protein kinases (PKA and PKG), second messengers and lipid signalling. While ...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2022-10-17 | PXD030057 | Pride
Toxoplasma gondii Calcium-signalling Egress Cdpk3 
GenomicsA super enhancer-controlled BRD4/ERα-RET-ERα positive feedback loop promotes ERα-positive breast cancer [ChIP-seq]
A super enhancer-controlled BRD4/ERα-RET-ERα positive feedback loop promotes ERα-positive breast cancer [ChIP-seq]
PRJNA774903 | ENA
GenomicsA super enhancer-controlled BRD4/ERα-RET-ERα positive feedback loop promotes ERα-positive breast cancer [RNA-seq]
A super enhancer-controlled BRD4/ERα-RET-ERα positive feedback loop promotes ERα-positive breast cancer [RNA-seq]
PRJNA774901 | ENA
GenomicsA super enhancer-controlled BRD4/ERα-RET-ERα positive feedback loop promotes ERα-positive breast cancer [GRO-seq]
A super enhancer-controlled BRD4/ERα-RET-ERα positive feedback loop promotes ERα-positive breast cancer [GRO-seq]
PRJNA774902 | ENA
GenomicsLINC00862 Inhibits Hepatocellular Carcinoma via a RBM47-mediated Positive Feedback Loop
LINC00862 Inhibits Hepatocellular Carcinoma via a RBM47-mediated Positive Feedback Loop
PRJNA981470 | ENA
GenomicsASIC3-M-CSF-M2 macrophage-positive feedback loop modulates in skin fibrosis pathogenesis
ASIC3-M-CSF-M2 macrophage-positive feedback loop modulates in skin fibrosis pathogenesis
PRJNA775894 | ENA
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