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ProteomicsMetabolic reprogramming in the airway epithelium of high risk individuals
We investigated proteins identified by shotgun proteomics in cytologically normal airway epithelial cells from individuals at different levels of risk for lung cancer. We identified 2869 proteins in bronchial brushings from individuals at low, moderate or high risk for lung cancer. Pathway analysis ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000079331 | MassIVE
TranscriptomicsMetabolic Reprogramming During Purine Stress in the Protozoan Pathogen Leishmania donovani
The ability of Leishmania to survive in their insect or mammalian host is dependent upon an ability to sense and adapt to changes in the microenvironment. However, little is known about the molecular mechanisms underlying the parasite response to environmental changes, such as nutrient availability....
ORGANISM(S): Leishmania donovani 
2014-02-01 | E-GEOD-48394 | biostudies-arrayexpress
ProteomicsMannose-6-phosphate isomerase functional status shapes a rearrangement in the proteome and degradome of mannose-treated melanoma cells
Metabolic reprogramming is a ubiquitous feature of transformed cells, comprising one of the hallmarks of cancer and enabling neoplastic cells to adapt to new environments. Accumulated evidence reports on the failure of some neoplastic cells to convert mannose-6-phosphate into fructose-6-phosphate, t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-16 | MSV000094098 | MassIVE
ProteomicsAntidiabetic PPARγ Antidiabetic PPARγ agonist Pioglitazone inhibits cell proliferation and induces metabolic reprogramming in prostate cancer cellsonist Pioglitazone inhibits cell proliferation and induces metabolic reprogramming in prostate cancer cells
Background: Prostate cancer (PCa) and Type 2 diabetes (T2D) are two major health risks that often occur concurrently in men. Studies predict that diabetic PCa patients have a reduced risk of PCa progression, while other studies show contradicting data. This impedes unraveling the connection between ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD060526 | Pride
Prostate cancer cells  ppar agonists  proteome and metabolic reprogramming 
ProteomicsProtective Effects of Mitochondrial Fission Inhibition on Ox-LDL Induced VSMC Foaming via Metabolic Reprogramming
Atherosclerosis (AS) is one of the most common diseases in middle-age and elderly population. Lipid metabolism disorder induced foaming of vascular smooth muscle cell (VSMC) is an important pathological process of AS. Mitochondria plays an important role in lipids metabolism. While it is not known w...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD035671 | Pride
Atherosclerosis；lipid deposition  foaming  mitochondrial fission  metabolic reprogramming 
ProteomicsComparative Tissue Proteomics for the Diagnosis of Indeterminate Pulmonary Nodules
We identified candidate protein biomarkers to distinguish lung adenocarcinomas from benign nodules. We employed shotgun proteomics using a multidimensional peptide separation approach coupled to tandem mass spectrometry (LC-MS/MS) to characterize proteomes of a collection of 34 benign lung nodules. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-09 | MSV000080236 | MassIVE
ProteomicsProfiling the molecular states in the mouse ischemia and reperfusion cortex reveals a core regulation module of metabolic reprogramming
Molecular changes caused by metabolic reprogramming in ischemia and reperfusion cortex remain an unaddressed issue. Applying the quantitative proteomic and lactylproteomic analysis, we found that the molecular changes of ischemic brain tissues are quite different between ischemia and reperfusion sta...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD019323 | Pride
Aldolase c Ischemia Metabolic reprogramming Lactylation Reperfusion 
MetabolomicsMulti-omics integration analysis reveals metabolic changes during sika deer antler growth

Background: Antler is an important economic trait of sika deer (Cervus nippon), capable of rapid growth without signs of tumorigenesis. However, the molecular mechanisms underlying its unique growth pattern remain poorly understood. This study conducted a combined transc...

2026-04-01 | MTBLS12622 | MetaboLights
ProteomicsHigh Fructose-Driven Epigenetic and Metabolic Reprogramming in Glomerular Podocyte
High fructose diet has been proposed as a major contributor to metabolic syndrome, which is usually accompanied with proteinuria due to glomerular podocyte injury. However, the underlying pathological mechanisms of fructose-induced podocyte injury remain elusive. In this study, we have used an iTRAQ...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-19 | PXD017849 | Pride
Itraq Rat High-fructose diet Podocyte injury Epigenetic mechanism. Mitochondria dysfunction Metabolic reprogramming 
ProteomicsStructural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity
The coordination of cellular signaling networks with metabolic response is key for balanced energy production and homeostasis. This coordination is achieved through spatiotemporal control of metabolism via compartmentalization and redundancies coupled to rapid signaling. Such dynamics must therefore...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-17 | PXD054497 | Pride
Phosphoproteomics Metabolomics Metabolism Lc-ms Cell signaling Obesity 
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