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TranscriptomicsGene expression analysis of RB1 knockdown in bone in response to radiation
The role of RB1 in response to radiation was examined in human osteoblasts. We demonstrate that RB1 induced SASP genes, a response which was attenuated in RB1 knockdown osteoblasts. Subconfluent hOB shEV and shRB1 cells were irradiated at 4 Gy using a 137Cesium source at a dose rate of 1.7 min/Gy a...
ORGANISM(S): Homo sapiens 
2013-09-14 | E-GEOD-50532 | biostudies-arrayexpress
ProteomicsGinsenoside Rb1 blocked mitochondrial reverse electron transfer-derived ROS production and protected cardiomyocytes from ischemia/reperfusion injury through reversibly inhibiting mitochondrial complex I
The management of cardiac ischemic injury has been challenged by ischemia and reperfusion (I/R) injury. Reactive oxygen species (ROS) generated from mitochondrial reverse electron transport (RET) during the early phase of reperfusion is considered to be the initiating cause for ischemia and reperfus...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD011414 | Pride
Rb1 Cardiomyocytes Lc-ms/ms Ros Proteome 
TranscriptomicsTranscription profiling of mouse Rb1 deficient Apc1638N cecal tumors vs duodenal tumors
To examine the role of Rb1 in gastrointestinal (GI) tumors we generated mice with an Apc1638N allele, Rbtm2brn floxed alleles, and a villlin-cre transgene (RBVCA). These mice had reduced median survival due to an increase in tumor incidence and multiplicity in the cecum and the proximal colon; they ...
ORGANISM(S): Mus musculus 
2008-11-13 | E-GEOD-13298 | biostudies-arrayexpress
ProteomicsDelineating the Rb1 interactome data and its modulations during cell cycle progression.
The retinoblastoma (Rb) protein is a potent tumor suppressor which is known to negatively regulate the cell cycle as well as tumor progression. Phosphorylated Rb protein (pRb) has been demonstrated to be in-charge for the key G1 checkpoint, blocking entry into S-phase and thereby the cell growth. Th...
ORGANISM(S): Homo sapiens (Human) 
2017-09-14 | PXD007708 | Pride
Rb1 Ap-ms Silac Interactome Tumor suppressor Cell cycle 
ProteomicsmicroRNA-4331 promotes TGEV-induced mitochondrial damage via targeting RB1, up-regulating IL1RAP, and activating p38 MAPK pathway in vitro
Transmissible gastroenteritis virus (TGEV), a member of the coronaviridae family, could cause fatal diarrhea of piglets and result in numerous economic losses. Previous studies demonstrated that TGEV infection could lead to mitochondrial damage and up-regulate miR-4331 level. So miR-4331 may play an...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2017-12-15 | PXD008174 | Pride
Micror-4331  mitochondrial damage  proteomics  transmissible gastroenteritis virus  rb1  il1rap  p38 mapk 
TranscriptomicsExpression data from Pou4f3-Rb1 cKO and control inner ear
Retinoblastoma gene (Rb1) is required for proper cell cycle exit in the developing mouse inner ear and its deletion in the embryo leads to proliferation of sensory progenitor cells that differentiate into hair cells and supporting cells. In the Pou4f3-Cre:Rb1 flox/flox (Rb1 cKO) inner ear, utricular...
ORGANISM(S): Mus musculus 
2011-05-31 | E-GEOD-25732 | biostudies-arrayexpress
TranscriptomicsRNA-seq of retinal organoids differentiated from hESCs carrying mutations in the RB1 gene
hESC lines carrying deleterious mutations in the RB1 gene in heterozygous and homozygous state were generated by genome-editing based on CRISPR/Cas9. Parental cell line and genome-edited cell lines were differentiated into retinal organoids for 152 days based on the Protocol published by Döpper et a...
ORGANISM(S): Homo sapiens 
2022-05-10 | E-MTAB-10331 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of acute Rb1 deletion in adult mouse tissues
Abstract:The pRb tumor suppressor protein associates with chromatin and regulates gene expression. Numerous studies have identified Rb-dependent RNA signatures, but the proteomic effects of Rb-loss are largely unexplored. We have acutely ablated Rb in adult mice and conducted quantitative analysis o...
ORGANISM(S): Mus musculus 
2015-09-11 | E-GEOD-71924 | biostudies-arrayexpress
ProteomicsProtein profiling of WERI RB1 and etoposide resistant WERI ETOR reveals new insights to overcome topoisomerase inhibitor resistance in retinoblastoma
Chemotherapy resistance is one of the reasons for the loss of the eye in retinoblastoma (RB) pa-tients. RB chemotherapy resistance has been investigated in different cell culture models like WERI RB1. Furthermore, chemotherapy resistant RB subclones like the etoposide resistant WERI ETOR cell line h...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030924 | Pride
Chemotherapy resistance Mass spectrometry Weri rb1 Weri etor Retinoblastoma 
TranscriptomicsMurine Prostate Tissue: Rb1 null vs. Rb1 E2F binding deficient mutant
Transcriptional profilling of 60 day old prostate tissue from Rb1F/F:Trp53F/F:PB-Cre4 or Rb1R654W/F:Trp53F/F:PB-cre4 mice versus wild type prostate tissue. Profiles used to compare deregulation of known E2F target genes in prostate tissue expressing a mutant Rb1 gene to tissue lacking Rb1 expression...
ORGANISM(S): Mus musculus 
2010-11-27 | E-GEOD-25615 | biostudies-arrayexpress
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