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TranscriptomicsJNK1 Ablation in Mice Confers Long-term Metabolic Protection from Diet-Induced Obesity at the Cost of Increased Skin Oxidative Damage
Obesity and insulin resistance are associated with oxidative stress, which may be implicated in their progression. The kinase JNK1 emerged as a promising drug target for the treatment of obesity and type-2 diabetes. However, JNK1 is a key mediator of the oxidative stress response, promoting either c...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-73759 | biostudies-arrayexpress
ProteomicsSpatially and cell-type resolved quantitative proteomic atlas of healthy human skin
Human skin provides both physical integrity and immunological protection from the external environment, using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins of skin have not been systematically charact...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-15 | MSV000088236 | MassIVE
TranscriptomicsSingle-cell RNAseq and scTCRseq of human CD8 T cells from blood and skin compartments in Dengue patients
Using a skin-blister induction model established for dengue, we investigated the transcriptional signatures and TCR repertoire of matched CD8 T cells in skin and blood samples
ORGANISM(S): Homo sapiens 
2026-04-14 | E-MTAB-16332 | biostudies-arrayexpress
GenomicsUV-protection timer controls a trade-off between skin protection systems
UV-protection timer controls a trade-off between skin protection systems
PRJNA472584 | ENA
TranscriptomicsSkin Resident Memory CD4+ T Cells Enhance Protection Against Leishmania Major Infection
Leishmaniasis causes a significant disease burden worldwide. Although Leishmania-infected patients become refractory to reinfection following disease resolution, effective immune protection has not yet been achieved by human vaccines. While circulating Leishmania-specific T cells are known to play...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-69998 | biostudies-arrayexpress
TranscriptomicsBulk RNA sequencing of day 2 and day 7 biopsies from the tuberculin skin test in people with latent tuberculosis
We used the tuberculin skin test (TST) as human challenge model to study the temporal evolution of the immune response to Mycobacterium tuberculosis (Mtb) antigens in vivo. Study participants comprised healthy HIV seronegative adults, 18-60 years of age. Latent tuberculosis (TB) infection was define...
ORGANISM(S): Homo sapiens 
2025-12-18 | E-MTAB-14687 | biostudies-arrayexpress
ProteomicsSpatially and cell-type resolved quantitative proteomic atlas of healthy human skin
Human skin provides both physical integrity and immunological protection from the external environment, using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins of skin have not been systematically charact...
ORGANISM(S): Homo sapiens (Human) 
2020-11-18 | PXD019909 | Pride
Protein expression T cell Skin Mass spectrometry Endothelial cells Macrophages Stratum corneum Interleukins Collagen Dermis Proteomics Melanocytes Mast cell Keratin Subcutis 
TranscriptomicsExpression data from human skin exposed to solar-simulated radiation with or without sunscreen
Despite widespread use of sunscreens that minimize erythema by blocking ultraviolet B (UVB) radiation, incidence rates of melanoma continue to rise. In considering this disparity between intervention and disease prevalence, we investigated the in vivo transcriptome of human skin treated with sunscr...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-22083 | biostudies-arrayexpress
ProteomicsIdentification of molecular targets of dietary grape-mediated chemoprevention of ultraviolet B skin carcinogenesis: a comparative quantitative proteomics analysis
Grape-supplemented SKH-1 tumor proteomics analysis. Two 10-plex TMT sample sets are included with each TMT sample set being comprised of 5 high pH fractions.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000084316 | MassIVE
TranscriptomicsUV-protection timer controls a trade-off between skin protection systems
Tanning is a skin protection mechanism against UV radiation. Pigment production initiates hours after exposure, and the mechanism controlling this delay was unknown. Here we reveal a skin UV-protection timer, governed by damped oscillatory dynamics of the melanocyte master regulator, MITF, which aft...
ORGANISM(S): Homo sapiens 
2018-10-26 | GSE114764 | GEO
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