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TranscriptomicsExpression profiling of the retinal pigment epithelium in zebrafish smarca4 mutant
Purpose: The purpose of this study was to develop a framework for analyzing RPE expression profiles from zebrafish eye mutants. Methods: The fish model we used was smarca4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4), a retinal dystrophic muta...
ORGANISM(S): Danio rerio 
2014-01-03 | E-GEOD-50241 | biostudies-arrayexpress
TranscriptomicsExamining the effect of SMARCA4–p53 regulatory axis on SCCOHT cells transcription
To examine the role SMARCA4-p53 regulatory axis in SCCOHT cells we performed RNA-seq in BIN-67 cells with SMARCA4 restoration, p53ko alone or combined with SMARCA4 and idasanutlin treatment (0.5μM, 24h) which increase the stability of p53 and its protein levels in SCCOHT.
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15707 | biostudies-arrayexpress
GenomicsAssessing SMARCA4 restoration contribution to global changes in p300 occupancy in BIN-67 cells
We aim to test how SMARCA4 restoration impacts p300 occupancy distribution. To this aim we generated ChIP-seq samples in BIN-67 with or without A-485 treatment (1 μM, 24h), as a proxy for p300 acetylatransferase inhibition, and BIN-67 with inducible SMARCA4 restoration (1 μg/ml Doxycycline for 24h)....
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15699 | biostudies-arrayexpress
GenomicsTo examine the role of p300 in the SMARCA4–p53 regulatory axis, we performed ChIP-seq to assess p300, p53, H3K27ac, HDAC1, HDAC2 occupancy in BIN-67 cells
ChIP-seq was performed in BIN-67, BIN-67 p53ko, BIN-67 with SMARCA4 restoration and BIN-67 p53ko cells with SMARCA4 restoration to assess the impact of SMARCA4 and p53 on the pull downs of p300, H3K27ac, p53, HDAC1 and HDAC2.
ORGANISM(S): Homo sapiens 
2026-05-05 | E-MTAB-15700 | biostudies-arrayexpress
ProteomicsSOX11-SMARCA4 Complex Drives Oncogenic Gene Regulation in Mantle Cell Lymphoma
SOX11 pioneer transcription factor is aberrantly expressed, it has an oncogenic role and its overexpression associates with worse prognosis in patients with mantle cell lymphomas (MCL). Using a proximity labeling (BioID2)/Mass Spectrometry-based proteomic strategyies, we identified SMARCA4, the cent...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD051143 | Pride
Smarca4 Cut&run-sequencing. Sry-related hmg-box 11 (sox11) Mantle cell lymphoma Swi/snf chromatin remodeling complex Pioneer transcription factor 
GenomicsSMARCA4 Rescue Profiling [ChIP]
SMARCA4 Rescue Profiling [ChIP]
PRJNA547548 | ENA
GenomicsSMARCA4 Rescue Profiling [Dnase]
SMARCA4 Rescue Profiling [Dnase]
PRJNA547550 | ENA
GenomicsSMARCA4 Rescue Profiling [RNA]
SMARCA4 Rescue Profiling [RNA]
PRJNA547549 | ENA
ProteomicsProteomic profiling of in vitro knockdown of SMARCA4 in Medulloblastoma
SMARCA4 mutations are common in Medulloblastoma but not much is understood about its pathobiology. In this study we prepared SMARCA4 knockdown models using a Group 3 medulloblastoma cell line called HDMB03 and investigated the proteomic changes. We performed both DDA and DIA analyses and found that ...
ORGANISM(S): Homo Sapiens (human) 
2026-03-25 | PXD070640 | JPOST Repository
ProteomicsProteomic profiling of nuclear fractions of SMARCA4 knockdown samples in HDMB03
SMARCA4 mutations are common in Medulloblastoma but not much is understood about its pathobiology. In this study we prepared SMARCA4 knockdown models using a Group 3 medulloblastoma cell line called HDMB03 and investigated the proteomic changes. Nuclear enrichment was performed using hypertonic and ...
ORGANISM(S): Homo Sapiens (human) 
2026-03-25 | PXD070641 | JPOST Repository
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