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ProteomicsMass Spectrometry Uncovers Protein Interactions and Stoichiometry of Intermediates and Sub-complexes for SNARE Complex Assembly
The neuronal SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 anchored to the presynaptic membrane. It mediates fusion of synaptic vesicles with the presynaptic plasma membrane resulting in exocytosis of neurotransmitters into the synaptic cleft. While the gene...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-25 | PXD030619 | Pride
Native mass spectrometry Chemical cross-linking Snare complex Complexin-1 Signal transmission in neurons 
ProteomicsSyntaxin5’s flexibility in SNARE pairing supports Golgi functions
The intracellular transport system is an evolutionally conserved, essential, and highly regulated network of organelles and small transport carriers that traffic protein and lipid cargoes within the cell. The Conserved Oligomeric Golgi (COG) complex is the major Golgi Multisubunit Tethering Complex....
ORGANISM(S): Homo sapiens (Human) 
2023-06-26 | PXD036741 | Pride
Membrane trafficking Golgi Bet1l Vti1b Snap29 Gor1 Gosr2 Cog Snares Stx5 Ykt6 
ProteomicsThe sodium leak channel NALCN is regulated by the neuronal SNARE complex
Chemical cross-linking coupled to mass spectrometry was used to study the subunit organization of the complex between human NALCN, FAM155A, SNAP25 and STX1A proteins. Cross-linking data was generated using the reagents disuccinimidyl suberate (DSS), pimelic dihydrazide (PDH), and 4-(4,6-dimethoxy-1,...
ORGANISM(S): Homo sapiens (Human) 
2025-02-20 | PXD053999 | Pride
Chemical cross-linking  dss  pdh  dmtmm  ion channel  sodium leak channel  nalcn  snare complex 
ProteomicsSerine ubiquitination of SNAREs generates bacterial vacuoles and prevents their lysosomal fusion
Here we show that Legionella SidE effectors mediate phosphoribosyl-linked serine ubiquitination (PR-Ub) of the autophagic SNARE proteins STX17 and SNAP29. On the one hand, PR-Ub modification of STX17 enhances its interaction with ATG14L, which drives the recruitment of ER membranes to the bacterial ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD058184 | Pride
Legionella pneumophila Xenophagy Syntaxin17 Ubiquitin Autophagy 
UnknownHOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex.
Not available
S-EPMC5385945 | biostudies-literature
UnknownMechanistic insights into the SNARE complex disassembly.
Not available
S-EPMC6457932 | biostudies-literature
UnknownAn activated Q-SNARE/SM protein complex as a possible intermediate in SNARE assembly.
Not available
S-EPMC5470040 | biostudies-literature
TranscriptomicsTranscription profiling of mouse macrophage response to LPS
RAW264.7 murine macrophages treated with LPS
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1459 | biostudies-arrayexpress
ProteomicsDeficiency in the SNARE protein SYNTAXIN-11 causes a secondary B cell defect
CD4 T cell help requires functional SNARE protein SYNTAXIN-11 for successful interaction with B cells, CD40L mobilization and secretion of IL-2 and IL-10 to promote B cell differentiation, germinal centre formation and class switch. STX11-deficieny results in hypogammaglobulinemia suggesting a highe...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-03-01 | MSV000094210 | MassIVE
UnknownReluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formation.
Not available
S-EPMC3150886 | biostudies-literature
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