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MetabolomicsTetrandrine regulates NAADP-mediated calcium signalling 1 through a novel LIMP-2-dependent, sphingosine-mediated mechanism.
Tetrandrine (Tet) is an highly potent inhibitor of Ebola virus replication by blocking NAADP51 dependent calcium release through endolysosomal two-pore channels (TPCs) and a moderately potent anti-tumor agent. Using a clickable, photoaffinity probe of Tet, we identified lysosomal integral membrane p...
2025-05-23 | MTBLS12492 | MetaboLights
ProteomicsTetrandrine regulates NAADP-mediated calcium signalling by a novel LIMP-2-dependent, sphingosine-mediated mechanism
Tetrandrine (Tet) is a highly potent inhibitor of Ebola virus replication by blocking NAADP-dependent calcium release through endolysosomal two-pore channels (TPCs) and is a moderately potent anti-tumor agent. Using a clickable, photoaffinity probe of Tet, we identified lysosomal integral membrane p...
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD064455 | Pride
Tetrandrine  limp-2  sphingosine-mediated mechanism  proteomics 
GenomicsTetrandrine regulates NAADP-mediated calcium signalling through a novel LIMP-2-dependent, sphingosine-mediated mechanism
Tetrandrine regulates NAADP-mediated calcium signalling through a novel LIMP-2-dependent, sphingosine-mediated mechanism
PRJNA876411 | ENA
ProteomicsSphingosine kinase 2 deficiency impairs VLDL secretion by inhibiting mTORC2 phosphorylation and activating chaperone-mediated autophagy
Hepatic very low-density lipoprotein (VLDL) is essential for maintaining lipid metabolism in the liver. Sphingosine kinases (SphKs) are essential rate-limiting enzymes that catalyze sphingosine phosphorylation to Sphingosine-1-phosphate (S1P). SphKs exist as two isoforms, SphK1 and SphK2, both highl...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-13 | PXD059594 | Pride
Sphk2 Cma Vldl Mtorc2 
UnknownActivation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation.
Not available
S-EPMC213794 | biostudies-literature
GenomicsOncogenic Modulation of MAPK Signaling in Leukemia via SPNS2-Mediated Sphingosine Metabolism Rewiring
Oncogenic Modulation of MAPK Signaling in Leukemia via SPNS2-Mediated Sphingosine Metabolism Rewiring
PRJNA1465656 | ENA
UnknownEpidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.
Not available
S-EPMC3714586 | biostudies-literature
UnknownTumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer.
Not available
S-EPMC9108620 | biostudies-literature
UnknownProximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.
Not available
S-EPMC3443517 | biostudies-literature
UnknownSphingosine kinase 2 deficiency impairs VLDL secretion by inhibiting mTORC2 phosphorylation and activating chaperone-mediated autophagy.
Not available
S-EPMC12500862 | biostudies-literature
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