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MetabolomicsSelective mTOR inhibition via FLCN drives TFE3-dependent VLDL-TG secretion and protects from MAFLD/MASH
Hepatic lipid homeostasis is controlled by multiple processes, including VLDL-TG secretion. We have previously shown that the FLCN/TFE3 branch of mTORC1 signaling controls hepatic fatty acid oxidation and de novo lipogenesis to protect mice from MAFLD. We now show that the FLCN/TFE3 pathway also con...
2026-09-08 | MTBLS15598 | MetaboLights
TranscriptomicsFenofibrate increases VLDL-triglyceride production despite reducing plasma triglyceride levels in APOE*3-Leiden.CETP mice
The PPAR? activator fenofibrate efficiently decreases plasma triglycerides (TG), which is generally attributed to enhanced VLDL-TG clearance and decreased VLDL-TG production. However, since data on the effect of fenofibrate on VLDL production are controversial, we aimed to investigate in (more) deta...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21211 | biostudies-arrayexpress
ProteomicsMS analyses of mouse VLDL from WT and ApoA5 (Apolipoprotein A-V) knockout mice
The impact of APOA5 on VLDL composition and its potential to alter VLDL metabolism in other ways remains poorly understood. To address this, we investigated the influence of APOA5 on the VLDL proteome. We used VLDL from Apoa5 knockout (KO) and wild-type (WT) mice, for mass spectrometry utilizing two...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-24 | PXD065274 | Pride
Mouse Knockout Vldl Apolipoprotein a-v 
ProteomicsVLDL Proteome in Control-AAV and PSS1(Q353R)-AAV
Fractionated VLDL from Control-AAV and PSS1(Q353R)-AAV.
ORGANISM(S): Mus musculus (Mouse) 
2024-10-21 | PXD047916 | Pride
Vldl Pss1 
ProteomicsSphingosine kinase 2 deficiency impairs VLDL secretion by inhibiting mTORC2 phosphorylation and activating chaperone-mediated autophagy
Hepatic very low-density lipoprotein (VLDL) is essential for maintaining lipid metabolism in the liver. Sphingosine kinases (SphKs) are essential rate-limiting enzymes that catalyze sphingosine phosphorylation to Sphingosine-1-phosphate (S1P). SphKs exist as two isoforms, SphK1 and SphK2, both highl...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-13 | PXD059594 | Pride
Sphk2 Cma Vldl Mtorc2 
MetabolomicsLeptin increases hepatic triglyceride export via a vagal mechanism in humans
Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative hypoleptinemia independent of its anorexic action. In rodents, leptin signaling in the brain increases very-low-density lipo...
2023-06-07 | MTBLS4231 | MetaboLights
GenomicsWGS of VLDL divergently selected fat and lean broilers
DNA sequencing of 8 individual broiler divergently selected for high and low VLDL
PRJEB15288 | ENA
TranscriptomicsFenofibrate increases VLDL-triglyceride production despite reducing plasma triglyceride levels in APOE*3-Leiden.CETP mice
The PPARα activator fenofibrate efficiently decreases plasma triglycerides (TG), which is generally attributed to enhanced VLDL-TG clearance and decreased VLDL-TG production. However, since data on the effect of fenofibrate on VLDL production are controversial, we aimed to investigate in (more) deta...
ORGANISM(S): Mus musculus 
2010-05-27 | GSE21211 | GEO
GenomicsSomatic mutations in TBX3 promote hepatic clonal expansion by accelerating VLDL secretion
Somatic mutations in TBX3 promote hepatic clonal expansion by accelerating VLDL secretion
PRJNA1282776 | ENA
GenomicsHyperlipidemia elicits an atypical, Th1 like CD4+ T cell response: a key role for VLDL
Hyperlipidemia elicits an atypical, Th1 like CD4+ T cell response: a key role for VLDL
PRJNA832283 | ENA
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