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GenomicsRNA sequencing of Sphk1fl/fl Sphk2-/- and Sphk1-/- Sphk2-/- mESC clones.
RNA sequencing of Sphk1fl/fl Sphk2-/- and Sphk1-/- Sphk2-/- mESC clones.
PRJNA587753 | ENA
ProteomicsSphingosine kinase 2 deficiency impairs VLDL secretion by inhibiting mTORC2 phosphorylation and activating chaperone-mediated autophagy
Hepatic very low-density lipoprotein (VLDL) is essential for maintaining lipid metabolism in the liver. Sphingosine kinases (SphKs) are essential rate-limiting enzymes that catalyze sphingosine phosphorylation to Sphingosine-1-phosphate (S1P). SphKs exist as two isoforms, SphK1 and SphK2, both highl...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-13 | PXD059594 | Pride
Sphk2 Cma Vldl Mtorc2 
TranscriptomicsHippocampal expression data from FTY720- and vehicle-treated SCID mice following fear consolidation testing
FTY720/Fingolimod, an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. Here we show that FTY720 enters the nucleus where it is phosphorylated by sphingosine kinase 2 (SphK...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-57015 | biostudies-arrayexpress
GenomicsPhosphorylation of SPHK2 by AMPK couples energy stress to nuclear S1P signaling in breast cancer
Phosphorylation of SPHK2 by AMPK couples energy stress to nuclear S1P signaling in breast cancer
PRJNA1367684 | ENA
UnknownSphK2 over-expression promotes osteosarcoma cell growth.
Not available
S-EPMC5739656 | biostudies-literature
TranscriptomicsPhosphorylation of SPHK2 by AMPK couples energy stress to nuclear S1P signaling in breast cancer
AMP-activated protein kinase (AMPK) orchestrates cellular responses to energy stress, yet its nuclear substrates remain incompletely characterized. Using quantitative phosphoproteomics on nuclear extracts from AMPKα1/α2 double-knockout and control myoblasts, we identified sphingosine kinase 2 (SPHK2...
ORGANISM(S): Homo sapiens 
2026-05-31 | GSE310986 | GEO
UnknownSphk2-/- mice are protected from obesity and insulin resistance.
Not available
S-EPMC6368224 | biostudies-literature
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Wild Type, SphK1-/- and SphK2-/- fibroblasts Transcriptomes
In numerous forms of organ injury, interstitial fibrosis is a final common pathway. Despite recent epidemiological studies, therapies to focus on fibrosis and to delay progressive renal failure are limited. Previously our group showed that sphingosine kinase 2 deficient-mice (SphK2-/-) develop less ...
ORGANISM(S): Mus musculus 
2019-09-01 | GSE103062 | GEO
GenomicsSphingosine kinase 2 (SphK2) knockout increases liver inflammation in an early MASH mouse model
Sphingosine kinase 2 (SphK2) knockout increases liver inflammation in an early MASH mouse model
PRJNA1176171 | ENA
UnknownMetabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis.
Not available
S-EPMC6938129 | biostudies-literature
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