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MetabolomicsExtracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness
The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...
2023-01-17 | MTBLS6661 | MetaboLights
MetabolomicsLactate controls cancer stemness and plasticity through epigenetic regulation.

Tumours arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumours, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs) and cancer differentiated cells (CDCs). This heterogen...

2025-05-28 | MTBLS11849 | MetaboLights
ProteomicsMesenchymal Stem Cells of Adipose Tissue Prone to Lose Their Stemness in Obesity Associated Stress Conditions
Obesity is a health problem characterized by large expansion of adipose tissue. During this expansion, genotoxic stressors can be accumulated and negatively affect the Mesenchymal Stem Cells (MSCs) of adipose tissue. Due to the oxidative stress generated by these genotoxic stressors, senescence phen...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD050811 | Pride
Obesity Stemness Senescence 
TranscriptomicsTrophoblast stem cells (TSC) global transcriptome in stemness and differentiation conditions after treatment with PF1-3
Here we report a potent, acetyl-lysine competitive and cell active inhibitor, PFI-3, that tightly binds to the bromodomain present in BRG1/BRM and the fifth bromodomain in Polybromo (BAF180). The high specificity of PFI-3 was achieved based on a novel binding mode of a salicylic acid head group that...
ORGANISM(S): Mus musculus 
2015-12-16 | E-GEOD-65358 | biostudies-arrayexpress
ProteomicsCPT1A-mediated MFF succinylation promotes stemness maintenance in ovarian cancer stem cells
Cancer stem cells (CSCs) play crucial roles in cancer progression, immune evasion, drug resistance, and recurrence. Understanding the mechanisms behind CSCs generation and stemness maintenance is vital for early cancer diagnosis and treatment. Here, we unveil that carnitine palmitoyltransferase 1A (...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059026 | Pride
Mff Stemness maintenance Cpt1a Ovarian cancer stem cells Mams 
ProteomicsSOX4 supports cancer stemness by enhancing HDAC1 transcription revealed by comparative proteomics
We have investigated the proteome changes induced by SOX4 overexpression in HCT-116 cells using iTRAQ-based quantitative proteomics. Bioinformatics analysis revealed that HDAC1 could be one of the important regulators in cancer stem cells (CSCs) maintenance. We found that SOX4 transcriptionally regu...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019694 | Pride
Sox4 Hdac1 Cancer stemness Comparative proteomics 
TranscriptomicsCancer-Associated Fibroblasts Support Lung Cancer Stemness through Paracrine IGF-II/IGF1R/Nanog Signaling
The CLS1/CAF co-culture maintained the cancer stemness. This cancer stemness was lost when the CAF feeder cells were removed during passaging. To investigate the specific signaling pathways and markers of lung CSCs, we analyzed the gene expression profile of the CLS1 sphere after CLS1/CAF co-cultur...
ORGANISM(S): Homo sapiens 
2014-03-25 | E-GEOD-38678 | biostudies-arrayexpress
ProteomicsSmall extracellular vesicles-delivered LSD1 promotes gastric cancer cell stemness
Although there are plenty of researches about nucleic acid in small extracellular vesicles (sEVs), properties of proteins identified as sEVs’ cargos and the mechanism of their action in recipient cell are poorly understood. Here, we show that lysine specific demethylase 1 (LSD1), the first identifie...
ORGANISM(S): Homo sapiens (Human) 
2021-07-30 | PXD021511 | Pride
Small extracellular vesicles  lsd1  stemness  gastric cancer 
TranscriptomicsEpigenetic Maintenance of Stemness and Malignancy in Peripheral Neuroectodermal Tumors by EZH2
Chromatin modifications are increasingly recognized as a key mechanism in cancer. The histone methyl-transferase Enhancer of Zeste, Drosophila, Homolog 2 (EZH2) is the enzymatic subunit of the polycomb PRC2 complex and methylates histone H3K27, thereby, mediating gene silencing. Down-regulation of E...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-15890 | biostudies-arrayexpress
GenomicsFIBP maintains colorectal cancer cells stemness via demethylation of stemness genes
FIBP maintains colorectal cancer cells stemness via demethylation of stemness genes
PRJNA412214 | ENA
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