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TranscriptomicsSOX4 effect on LNCaP prostate cancer cells
This SuperSeries is composed of the following subset Series: GSE11874: Chromatin Immunoprecipitation microarray data from antiHA IP in stable LNCaP cells expressing either YFP or HA-SOX4/YFP GSE11913: Illumina expression data from LNCaP cells overexpressing either SOX4 or GFP GSE11914: Expression da...
ORGANISM(S): Homo sapiens 
2008-11-09 | E-GEOD-11915 | biostudies-arrayexpress
TranscriptomicsExpression data from Sox4 knockdown cells in the presence and absence of TGFβ in NMuMG cells
Expression profiling after Sox4 knockdown (KD) during epithelial to mesenchymal transition (EMT) in NMuMG reveals a significant number of genes that are transcriptionally deregulated. Gene expression profiling is performed in Sox4-ablated (siSox4) NMuMG cells. Cells transfected with siControl is use...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-44050 | biostudies-arrayexpress
GenomicsSOX4 genome binding targets in glioblastoma cell line
Overexpression of SOX4 in LN229 glioblastoma cells prevents their cell cycle Examination of SOX4 binding profile in prostate cell LN229-SOX4 with LN229-GFP as negative control.
ORGANISM(S): Homo sapiens 
2014-10-20 | E-GEOD-51663 | biostudies-arrayexpress
TranscriptomicsIdentification of SOX4 novel transcriptional targets.
The SOX4 gene belongs to a family of transcription factors and we previously unveiled SOX4 gene amplification and over-expression in a subset of lung cancers, indicating it may constitute a driver oncogene. Here, we searched for SOX4 transcriptional targets and investigate their involvement in lung ...
ORGANISM(S): Homo sapiens 
2011-11-18 | E-GEOD-31612 | biostudies-arrayexpress
TranscriptomicsSox4 links tumor suppression to accelerated aging in mice [Telogen]
Sox4 is a transcription factor expressed during embryonic development and some adult tissues such as lymphoid organs, pancreas, intestine and skin. During embryogenesis, Sox4 regulates the survival of mesenchymal and neural progenitors, lymphocyte and myeloid differentiation, and pancreatic, bone an...
ORGANISM(S): Mus musculus 
2015-05-20 | E-GEOD-58154 | biostudies-arrayexpress
GenomicsUnraveling the Sox4-orchestrated pro-B cell differentiation program: Intricate roles of the RAG and CK1ε genes (ChIP-Seq)
Commitment of hematopoietic stem cells to B lineage precursors and development of B lineage precursors into mature B cells is attained through the coordinated function of multiple signaling networks, which are in turn controlled through stringent functioning of stage-specific transcription factors. ...
ORGANISM(S): Mus musculus 
2014-07-02 | E-GEOD-50066 | biostudies-arrayexpress
ProteomicsSOX4 supports cancer stemness by enhancing HDAC1 transcription revealed by comparative proteomics
We have investigated the proteome changes induced by SOX4 overexpression in HCT-116 cells using iTRAQ-based quantitative proteomics. Bioinformatics analysis revealed that HDAC1 could be one of the important regulators in cancer stem cells (CSCs) maintenance. We found that SOX4 transcriptionally regu...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019694 | Pride
Sox4 Hdac1 Cancer stemness Comparative proteomics 
TranscriptomicsSox4 links tumor suppression to accelerated aging in mice [Hair regeneration]
Sox4 is a transcription factor expressed during embryonic development and some adult tissues such as lymphoid organs, pancreas, intestine and skin. During embryogenesis, Sox4 regulates the survival of mesenchymal and neural progenitors, lymphocyte and myeloid differentiation, and pancreatic, bone an...
ORGANISM(S): Mus musculus 
2015-05-20 | E-GEOD-58153 | biostudies-arrayexpress
TranscriptomicssiRNA profiling of human LNCaP cells transfected with SOX4 cDNA, SOX4 siRNA or GFP cDNA
SOX4 is a critical developmental transcription factor in vertebrates and is required for precise differentiation and proliferation in multiple tissues. In addition, SOX4 is overexpressed in many human malignancies, but the precise role of SOX4 in cancer progression is not well understood. He...
ORGANISM(S): Homo sapiens 
2008-11-14 | E-GEOD-11914 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of Sox4 in a human adenoid cystic carcinoma cell line reveals that knockdown of Sox4 expression induces apoptosis
Sox4 is upregulated in adenoid cystic carcinoma (ACC). The ACC3 cell line is the most widely available cell culture model system of this tumor type. RNAi mediated knockdown of Sox4 in ACC3 cells induces apoptosis.
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-4225 | biostudies-arrayexpress
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