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Rat brain synaptosomes were used to study effects of calcium and synaptic vesicle cycling on protein phosphorylation following potassium chloride-induced depolarization.
ORGANISM(S): Homo sapiens (Human) Clostridium botulinum A str. Hall Rattus norvegicus (Rat) 
2021-02-17 | PXD020564 | Pride
Aging synaptosomes
Parkinson´s disease (PD) feature a progressive degeneration of dopaminergic neurons in the substantia nigra (SN). Additionally, numerous studies indicate an altered synaptic function during the course of PD. In order to characterize the proteome of synaptosomes isolated from the substantia nigra and...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD022092 | Pride
Mammalian target of rapamycin (mTOR) is implicated in synaptic plasticity and local translation in dendrites. Here we found that the mTOR inhibitor, rapamycin, increased the Kv1.1 voltage-gated potassium channel protein in hippocampal neurons and promoted Kv1.1 surface expression on dendrites withou...
ORGANISM(S): Rattus norvegicus 
Neurons communicate at synapses through the release of neurotransmitters (NT). These NTs are stored in synaptic vesicles (SVs) at the presynaptic nerve terminal, where they undergo a trafficking cycle consisting of Ca2+-triggered SV exocytosis, SV endocytosis and regeneration. While protein phosphor...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-04-18 | PXD052826 | Pride
Transcriptome analysis of synaptosomes in ageing
RNAs associated with ribosomes in aging synaptosomes
Synaptic small and total RNAome from hippocampal Synaptosomes and the synaptic compartments of microfluidic chambers
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