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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
GenomicsMolecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae
Pseudomonas syringae uses two-component system RhpRS to regulate the expression of type III secretion system (T3SS) genes and bacterial virulence. However, the molecular mechanism and the regulons of RhpRS have yet to be fully elucidated. Here we show that RhpS functions as an autokinase, an RhpR ki...
ORGANISM(S): Pseudomonas syringae pv. phaseolicola 
2014-10-01 | E-GEOD-58533 | biostudies-arrayexpress
ProteomicsThe promiscuous biotin ligase TurboID reveals the proxisome of the T3SS chaperone IpgC in the cytoplasm of Shigella flexneri
Using TurboID to study the proxisome of Shigella flexneri's Type 3 Secretion System (T3SS) chaperone IpgC, and transcriptional activator MxiE. The proxisome was studied in the ON (active secretion) and OFF (inactive secretion) states of the T3SS using N and C -terminal fusions of TurboID to the bait...
ORGANISM(S): Shigella Flexneri 5a Str. M90t (ncbitaxon:1086030) 
2024-07-29 | MSV000095473 | MassIVE
ProteomicsBtcB (BP2265) is a T3SS chaperone of the CesT family in Bordetella pertussis
Bordetella pertussis is a Gram-negative, strictly human respiratory pathogen and the causative agent of whooping cough (pertussis). Similar to other Gram-negative pathogens, B. pertussis produces a functional type III secretion system, but its role in pathogenesis of B. pertussis is enigmatic and ha...
ORGANISM(S): Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) Bordetella pertussis B1917 
2024-01-26 | PXD044487 | Pride
Lc-msms T3ss Bordetella pertussis Rna-seq 
GenomicsBP2265 is a chaperone of T3SS anti-sigma factor BtrA in Bordetella pertussis
New T3SS chaperone BP2265
PRJEB65304 | ENA
ProteomicsVibrio campbellii BB120 T3SS secretome
Identifying the T3SS secretome of the marine bacterium Vibrio cambpellii BB120.
ORGANISM(S): Vibrio campbellii ATCC BAA-1116 
2026-03-09 | PXD074406 | Pride
T3ss Effector Vibrio 
GenomicsIncreased Plasmid Copy-number is Essential for Yersinia T3SS Function and Virulence
Increased Plasmid Copy-number is Essential for Yersinia T3SS Function and Virulence
PRJEB13406 | ENA
GenomicsPseudomonas aeruginosa PAK
Pseudomonas aeruginosa T3SS screen
PRJNA849930 | ENA
GenomicsPseudomonas aeruginosa PA103
Pseudomonas aeruginosa T3SS screen
PRJNA849614 | ENA
TranscriptomicsGene regulation by the RcsCB two-component system and the auxiliary protein TviA in S. Typhi
In response to osmolarity, Salmonella enterica serotype Typhi (S. Typhi) regulates genes required for Vi capsular antigen expression oppositely to those required for motility and invasion. Previous studies suggest that osmoregulation of motility, invasion and capsule expression is mediated through t...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhi 
2010-05-18 | E-GEOD-15752 | biostudies-arrayexpress
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