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ProteomicsSILAC-iTRAQ-TAILS - Monitoring matrix metalloproteinase activity at the epidermal-dermal interface by SILAC-iTRAQ-TAILS
Secreted proteases act on interstitial tissue secretomes released from multiple cell types. Thus, substrate proteins might be part of higher molecular complexes constituted by many proteins with diverse and potentially unknown cellular origin. In cell culture these might be reconstituted by mixing n...
ORGANISM(S): Mus musculus (Mouse) 
2015-05-11 | PXD001643 | Pride
Skin Basement membrane Tails Silac Itraq Mmp 
ProteomicsHuman Dental Pulp TAILS N-terminomics
We report the targeted analysis of the human dental pulp proteome and N-terminome using the positional proteomics technique TAILS, which allowed us to capture both naturally blocked and unblocked protein N-termini. Furthermore, by using a proteomically barely studied human tissue in combination with...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-06-26 | MSV000082509 | MassIVE
ProteomicsTAILS proteomics of murine pancreatic tumors
Aberrant proteolysis by cysteine cathepsins is implicated in carcinogenesis, but knowledge of cathepsin substrates mediating tumor-promoting or suppressing effects is limited. Here we characterize tumor proteome and in vivo cathepsin substrates using cathepsin knockout mice and the RIP1-Tag2 model o...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-08 | PXD003637 | Pride
Pancreatic neuroendocrine cancer Ecm Proteomics Substrate discovery Proteolytic processing Degradation Proteases Tails n-terminomics Cysteine cathepsins 
ProteomicsN-terminomics/TAILS profiling of proteases and their substrates in ulcerative colitis
Dysregulated protease activity is often implicated in the initiation of inflammation and immune cell recruitment in gastrointestinal inflammatory diseases. Using N-terminomics/TAILS (terminal amine isotopic labeling of substrates), we compared proteases, along with their substrates and inhibitors, b...
ORGANISM(S): Homo sapiens (Human) 
2019-09-08 | PXD014479 | Pride
Protease Biopsies Ulcerative colitis Tails 
ProteomicsExploring the mitochondrial degradome by the TAILS proteomics approach in a cellular model of Parkinsons disease
Development of a degradomics strategy which combines the isolation of mitochondria (surfactants-based method) with the dimethylation-TAILS protocol for N-terminome enrichment.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-05-17 | MSV000083795 | MassIVE
ProteomicsTAILS identifies candidate substrates and biomarkers of ADAMTS7, a therapeutic protease target in coronary artery disease
MacDonald BT, Keshishian H, Mundorff CC, Arduini A, Lai D, Bendinelli K, Popp NR, Bhandary B, Clauser KR, Specht H, Elowe NH, Laprise D, Xing Y, Kaushik VK, Carr SA, Ellinor PT. Loss-of-function mutations in the secreted enzyme ADAMTS7 (a disintegrin and metalloproteinase with thrombospondin motifs ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-03 | MSV000088508 | MassIVE
Proteomicsmito-TAILS analysis of EPEC infection
Mito-TAILS N-terminomics analysis of proteolytic events during EPEC infection of human epithelial cells, on whole-cell level and mitochondria.
ORGANISM(S): Homo sapiens (Human) 
2020-05-21 | PXD016994 | Pride
Epec Infection Tails Proteolysis 
ProteomicsHuman Dental Pulp TAILS N-terminomics
We report the targeted analysis of the human dental pulp proteome and N-terminome using the positional proteomics technique TAILS, which allowed us to capture both naturally blocked and unblocked protein N-termini. Furthermore, by using a proteomically barely studied human tissue in combination with...
ORGANISM(S): Homo sapiens (Human) 
2015-08-18 | PXD002264 | Pride
Human Agilent g6550a q-tof Dental pulp Tails n-terminomics Lc-ms/ms 
ProteomicsTAILS N-terminomics of the human dental pulp stroma and the odontoblast layer
We report the targeted analysis of the human dental pulp stroma and the odontoblast layer using the positional proteomics technique TAILS N-terminomics, which allowed us to capture both naturally blocked and unblocked protein N-termini, and to identify differences between e.g. the dental pulp proteo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-10 | MSV000083951 | MassIVE
TranscriptomicsPoly(A)-tail profiling reveals an embryonic switch in translational control
Poly(A) tails enhance the stability and translation of most eukaryotic messenger RNAs, but difficulties in globally measuring poly(A)-tail lengths have impeded greater understanding of poly(A)-tail function. Here we describe poly(A)-tail length profiling by sequencing (PAL-seq) and apply it to measu...
ORGANISM(S): Arabidopsis thaliana 
2014-01-29 | E-GEOD-52809 | biostudies-arrayexpress
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