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TranscriptomicsU-87 MG Temozolomide-Induced Senescence RNA-seq Dataset
We analyzed the U-87 MG cell line, which was treated with temozolomide for 5 days to induce a senescent state. The study aimed to investigate molecular and phenotypic alterations associated with senescence in the context of a malignant phenotype. Senescence was confirmed through β-galactosidase stai...
ORGANISM(S): Homo sapiens 
2025-05-14 | E-MTAB-15106 | biostudies-arrayexpress
ProteomicsCytoplasmic Proteomics for Temozolomide Resistance in Glioblastoma
TMZ resistance is one of the main reasons why treatment of glioblastoma (GBM) fails. In order to investigate the underlying mechanism associated with TMZ resistance, we conducted a cytoplasmic proteome research of U87 cells treated with TMZ for 1 week. A total of 162 DEPs including 66 up-regulated p...
ORGANISM(S): Homo sapiens (Human) 
2018-10-23 | PXD007759 | Pride
Glioblastoma  temozolomide resistance  subcellular proteomics 
ProteomicsMulti-omics Analyses Reveal Mitochondrial Dysfunction Con-tributing to Temozolomide Resistance in Glioblastoma Cells
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor with poor prognosis. Temozolomide (TMZ) is the standard chemotherapy for glioblastoma treatment, but TMZ resistance significantly compromises its efficacy. In the present study, we generated a TMZ-resistant cell line and iden...
ORGANISM(S): Homo Sapiens 
2023-09-13 | PXD045376 |
GenomicsGenomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells
Genomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells
PRJNA939161 | ENA
GenomicsRegulation of temozolomide resistance by m6A mRNA methylation in glioma cell lines
Regulation of temozolomide resistance by m6A mRNA methylation in glioma cell lines
PRJNA1311120 | ENA
ProteomicsClass I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression
Overexpression of histone deacetylases (HDACs) in cancer commonly causes resistance to genotoxic based therapies. Here we report on the novel mechanism whereby overexpressed class I HDACs increase the resistance of glioblastoma cells to the SN1 methylating agent temozolomide (TMZ). The chemotherapeu...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD028683 | Pride
Lc-ms/ms 
TranscriptomicsTranscription profiling of human-melanoma derived cell lines response to chemotherapy
To identify patterns of gene expression that correlate with response to treatment with either melphalan or temozolomide we measured both gene expression using microarray genechips and response to drug using a standard in vitro cell proliferation assay. Senstivity to melphalan was measured 48hrs aft...
ORGANISM(S): Homo sapiens 
2009-02-09 | E-GEOD-10916 | biostudies-arrayexpress
ProteomicsTemozolomide Induces Glioblastoma Dedifferentiation into Highly Malignant Stem-like Cells Through Senescence-Associated Reprogramming via HIF1α/HIF2α Regulation
A critical issue is that recurrent glioblastoma multiforme (GBM) after temozolomide (TMZ) exposure becomes more malignant, exhibiting higher invasion and stemness than the primary tumor. However, the detailed mechanism remains to be elucidated. While the majority of GBM cells succumb to TMZ treatmen...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058156 | Pride
Temozolomide Glioblastoma 
TranscriptomicsGenomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells
Temozolomide resistance is a major obstacle in the therapy of glioblastoma. This is also due to the insufficient understanding of glioma heterogeneity in relation to temozolomide resistance. More in depth biological knowledge would benefit the development of different approaches to tackle the proble...
ORGANISM(S): Homo sapiens 
2023-10-24 | GSE226202 | GEO
ModelsStephanou2019 - pH as a potential therapeutic target to improve temozolomide antitumor efficacy
Abstract: Despite intensive treatments including temozolomide (TMZ) administration, glioblastoma patient prognosis remains dismal and innovative therapeutic strategies are urgently needed. A systems pharmacology approach was undertaken to investigate TMZ pharmacokinetics‐pharmacodynamics (PK‐PD) inc...
2019-09-30 | MODEL1909300003 | BioModels
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