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MetabolomicsGut microbiota-mediated histidine deficiency drives testicular ferroptosis induced by bisphenol F exposure

Bisphenol F (BPF), a widespread environmental contaminant and a major substitute for the restricted bisphenol A (BPA), has raised increasing concerns regarding its potential male reproductive health risks, yet its underlying mechanisms remain poorly understood. This study investigates t...

2026-05-26 | MTBLS13997 | MetaboLights
TranscriptomicsTranscription profiling of testicular seminoma tumour stages (pT1, pT2, pT3) and 3 normal testes
Gene expression patterns of testicular seminoma were analysed applying oligonucleotide microarrays in 40 specimens of different tumour stages (pT1, pT2, pT3) and in 3 normal testes. Experiment Overall Design: A total of 40 pure seminoma including 22 samples of tumour stage 1 (pT1), 14 samples of tum...
ORGANISM(S): Homo sapiens 
2008-11-06 | E-GEOD-8607 | biostudies-arrayexpress
TranscriptomicsTesticular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain
Chromosome substitution strains (CSS or consomic strains) are useful for mapping phenotypes to chromosomes. However, huge efforts are needed to identify the gene(s) responsible for the phenotype in the complex context of the chromosome. Here, we report the identification of candidate disease genes...
ORGANISM(S): Mus musculus 
2009-01-13 | E-GEOD-14354 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human testicular tissue histologically scored as containing carcinoma in situ (CIS) in 50%, 75%, and 100% of the seminiferous tubules vs total RNA from testicular tissue with preserved normal and complete spermatogenesis and no CIS present
Total RNA from testicular tissue histologically scored as containing carcinoma in situ (CIS) in 50%, 75%, and 100% of the seminiferous tubules and total RNA from testicular tissue with preserved normal and complete spermatogenesis and no CIS present were isolated, amplified, labeled, and co-hybridiz...
ORGANISM(S): Homo sapiens 
2004-07-15 | E-EMBL-2 | biostudies-arrayexpress
TranscriptomicsCynomolgus monkey testicular cDNAs for discovery of novel human genes
BACKGROUND: In order to contribute to the establishment of a complete map of transcribed regions of the human genome, we constructed a testicular cDNA library for the cynomolgus monkey, and attempted to find novel transcripts for identification of their human homologues. RESULT: The full-insert sequ...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-513 | biostudies-arrayexpress
TranscriptomicsA molecular and phenotypic integrative approach to identify a no effect dose level for anti-androgen induced testicular toxicity
With the advent of high information content technologies, especially microarrays, it is pertinent to determine the impact of molecular data on the NOAELs. Consequently, we conducted an integrative study to identify a no transcriptomic effect dose using microarray analyses coupled with qPCR and deter...
ORGANISM(S): Rattus norvegicus 
2011-03-29 | E-GEOD-28202 | biostudies-arrayexpress
TranscriptomicsTesticular lumicrine factors regulate ERK, STAT and NFKB pathways in the initial segment of the rat epididymis to prevent apoptosis
The initial segment of the epididymis is vital for male fertility, therefore, it is important to understand the mechanisms that regulate this important region. Deprival of testicular luminal fluid factors/lumicrine factors from epididymis, a subset of cells within the initial segment undergo apoptos...
ORGANISM(S): Rattus norvegicus 
2011-03-11 | E-GEOD-21806 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal, premalignant and various histological subtypes of testicular germ cell tumor (TGCT) tissues, and of two TGCT cell lines treated with retinoic acid
Normal, premalignant and various histological subtypes of testicular germ cell tumor (TGCT) tissues were hybridized against Universal Human Reference RNA (Stratagene) onto Agilent 60mer oligo microarrays (GEO accession no GPL885). In vitro time series of two TGCT cell lines, NTERA2 and 2102Ep, treat...
ORGANISM(S): Homo sapiens 
2008-05-07 | E-GEOD-1818 | biostudies-arrayexpress
TranscriptomicsmRNA expression of cancer and matched adjacent tissues of 7 testicular germ cell tumors and 10 transitional cell carcinomas of bladder
Genome-wide gene expression profile using deep sequencing technologies can drive the discovery of cancer biomarkers and therapeutic targets. Such efforts are often limited to profiling the expression signature of either mRNA or microRNA (miRNA) in a single type of cancer.Here we provided an integrat...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-31614 | biostudies-arrayexpress
ProteomicsProteomics of Mouse Testicular Organoids on Day 6
To investigate the mechanism for the formation of tubule-like structures in testicular organoids, we conducted proteomic analysis on O-Torgs and T-Torgs at day 6. Through differential protein expression and enrichment analysis, it was found that the extracellular matrix (ECM) related pathways in O-...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-26 | PXD075407 | Pride
Lc-msms Mouse Testicular organoids 
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