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ProteomicsβIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling
Defective angiogenesis underlies over 50 malignant, ischemic and inflammatory disorders yet long-term therapeutic applications inevitably fail, thus highlighting the need for greater understanding of the vast crosstalk and compensatory mechanisms. Based on proteomic profiling of angiogenic endotheli...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-04 | PXD026618 | Pride
Sprouting angiogenesis  vegf signaling  tip-stalk cell specification  spectrins 
ProteomicsGraded levels of p53 activation modulate endothelial cell fate and specification during angiogenesis
The cell cycle is a key regulator of endothelial cell specification into tip and stalk cell phenotypes, which are essential for angiogenesis in both normal development and pathological conditions. While the tumor suppressor p53 is known to regulate the cell cycle and influence cell fate, its role in...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD060120 | Pride
Angiogenesis P53 
TranscriptomicsEndothelin2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis
Endothelin signaling is required for neural crest migration and homeostatic regulation of blood pressure. Here we report that constitutive over-expression of Endothelin-2 (Edn2) in the mouse retina perturbs vascular development by inhibiting endothelial cell (EC) migration across the retinal surfac...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-50059 | biostudies-arrayexpress
UnknownSpatial-temporal order-disorder transition in angiogenic NOTCH signaling controls cell fate specification.
Not available
S-EPMC10942579 | biostudies-literature
UnknownPI(4,5)P2-dependent regulation of endothelial tip cell specification contributes to angiogenesis.
Not available
S-EPMC10065449 | biostudies-literature
UnknownPharmacological activation of p53 induces dose-dependent changes in endothelial cell fate during angiogenic sprouting.
Not available
S-EPMC12698774 | biostudies-literature
UnknownMatrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis.
Not available
S-EPMC8379356 | biostudies-literature
UnknownAngiogenesis-on-a-chip coupled with single-cell RNA sequencing reveals spatially differential activations of autophagy along angiogenic sprouts.
Not available
S-EPMC10764361 | biostudies-literature
UnknownβIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling.
Not available
S-EPMC8921520 | biostudies-literature
UnknownAnxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification.
Not available
S-EPMC6156511 | biostudies-literature
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