Sort   by:  
 Page size 
ProteomicsTRIM21 enhances bortezomib sensitivity in multiple myeloma by halting pro-survival autophagy
Bortezomib (bort) is an effective therapeutic agent for multiple myeloma (MM) patients; however, the majority of patients develop drug resistance. Autophagy, a highly conserved process that recycles cytosol or entire organelles via lysosomal activity, is essential for the survival, homeostasis and d...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042004 | Pride
Trim21 multiple myeloma bortezomib 
ProteomicsThe mechanism of TRIM21 inhibiting the invasion and migration of ccRCC by stabilizing ASS1
Clear cell renal cell carcinoma (ccRCC) is characterized by its aggressive invasion and metastasis, posing significant clinical challenges. Understanding the molecular mechanisms underlying its progression is crucial for developing effective therapeutic strategies. The role of TRIM21 in regulating A...
ORGANISM(S): Homo Sapiens 
PXD054847 |
GenomicsEffect of Trim21 knockdown on MAPK and ERBB signaling pathways
Effect of Trim21 knockdown on MAPK and ERBB signaling pathways
PRJNA860116 | ENA
GenomicsThe autoantigen TRIM21 assembles proinflammatory immune complexes following lytic cell death
The autoantigen TRIM21 assembles proinflammatory immune complexes following lytic cell death
PRJNA1420722 | ENA
GenomicsPa01c cells stable expressing a scramble or shRNA against TRIM21
Pa01c cells stable expressing a scramble or shRNA against TRIM21
PRJNA857441 | ENA
ProteomicsTRIM21 innate immune detection of GBP1-positive Toxoplasma gondii is essential for host survival
Interferon gamma (IFN) is the major pro-inflammatory cytokine conferring resistance to the intracellular vacuolar pathogen Toxoplasma gondii. Autophagy along with immunity-related GTPases (IRGs), guanylate binding proteins (GBPs) and the E3 ubiquitin ligase TNF receptor-associated factor 6 (TRAF6) m...
ORGANISM(S): Mus musculus (Mouse) Toxoplasma gondii ME49 
2018-03-12 | PXD003217 | Pride
Proteomics Toxoplasma gondii Trim21 
GenomicsTRIM21 aggravates cardiac injury after myocardial infarction via promoting M1 macrophage polarization
TRIM21 aggravates cardiac injury after myocardial infarction via promoting M1 macrophage polarization
PRJNA886696 | ENA
GenomicsTranscriptional profiling of colon cancer tumors in mice with Trim21 gene Knock out
Transcriptional profiling of colon cancer tumors in mice with Trim21 gene Knock out
PRJNA1072707 | ENA
ProteomicsElaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates
Approaches for the discovery of molecular glues remain limited. Here we report a phenotypic screening approach in which cytotoxins whose mechanisms require ubiquitination show gain of viability following pharmacological inhibition of the Ubiquitin-life modifier activating enzyme (UBA1/UAE). This a...
ORGANISM(S): Homo sapiens (Human) 
2025-06-17 | PXD062839 | Pride
Nucleoporin Targeted protein degradation Molecular glue degraders Protac 
ProteomicsPPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
Our study have shown that PPDPF promoted NF-κB activation through TRIM21-mediated K63-linked ubiquitination of RIPK1 in hepatocytes. Upon TNF-α stimulation, PPDPF enhances TRIM21/RIPK1 interaction and increases TRIM21-mediated K63-linked ubiquitination of RIPK1, which promotes NF-κB activation.To ma...
ORGANISM(S): Homo Sapiens 
2023-02-21 | PXD040301 |
Sort   by:  
 Page size