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ProteomicsPeli1-mediated TSC1 ubiquitination site
Metabolic fitness of T cells is crucial for immune responses against infections and tumorigenesis. Both the T cell receptor (TCR) signal and environmental cues contribute to the induction of T cell metabolic reprogramming, but the underlying mechanism is incompletely understood. Here we identified t...
ORGANISM(S): Homo sapiens (Human) 
2020-11-23 | PXD020734 | Pride
Peli1  tsc1  ubiquitination 
ProteomicsDrosophila S2R+ / TSC1 / TSC2 mutant phosphoproteomics
The tuberous sclerosis complex (TSC) family of tumor suppressors, TSC1 and TSC2, function together in an evolutionarily conserved protein complex that is a point of convergence for major cell signaling pathways that regulate mTOR complex 1 (mTORC1). Mutation or aberrant inhibition of the TSC complex...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-10-24 | PXD002670 | Pride
Tsc2 Drosophila Tsc1 Phosphoproteomics 
TranscriptomicsTuberous sclerosis complex 1 (Tsc1) enforces quiescence of naive T cells to promote immune homeostasis and function
The mechanisms that regulate T cell quiescence are poorly understood. We report that tuberous sclerosis complex 1 (Tsc1) establishes a quiescent program in naïve T cells by controlling cell size, cell cycle entry, and responses to T cell receptor stimulation. Loss of quiescence predisposed Tsc1-de...
ORGANISM(S): Mus musculus 
2011-07-11 | E-GEOD-29797 | biostudies-arrayexpress
TranscriptomicsTsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs
Memory CD8+ T cells are an essential component of protective immunity. Signaling via mechanistic target of rapamycin (mTOR) has been implicated in the regulation of the differentiation of effector and memory T cells. However, little is understood about the mechanisms that control mTOR activity, or t...
ORGANISM(S): Mus musculus 
2014-09-20 | E-GEOD-61591 | biostudies-arrayexpress
GenomicsBulk RNAseq Analysis of Murine Thoracic Aortas with Tsc1+/+ and Tsc1-/- Smooth Muscle Cells
Bulk RNAseq Analysis of Murine Thoracic Aortas with Tsc1+/+ and Tsc1-/- Smooth Muscle Cells
PRJNA557674 | ENA
GenomicsSingle-Cell RNAseq Analysis of Murine Fate-Mapped Tsc1+/+ and Tsc1-/- Aortic Smooth Muscle Cells
Single-Cell RNAseq Analysis of Murine Fate-Mapped Tsc1+/+ and Tsc1-/- Aortic Smooth Muscle Cells
PRJNA558136 | ENA
ProteomicsProfiling the surfaceome identifies therapeutic targets for cells with hyperactive mTORC1 signaling
Aberrantly high mTORC1 signaling is a known driver of many cancers and human disorders, yet pharmacological inhibition of mTORC1 rarely confers durable clinical responses. To explore alternative therapeutic strategies, herein we conducted a proteomics survey to identify cell surface proteins upregul...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-06-17 | MSV000083988 | MassIVE
ProteomicsS6K1 Phosphoproteome in Tsc1-null mouse kidney iMCD3 cells
Loss of Tsc1 in the kidneys gives rise to rapid polycystogenesis and kidney failure due to the hyperactivation of mTOR complex I (mTORC1). One of the major downstream targets of mTORC1 is S6K1, which is responsible for driving many of the effector functions of mTOR. Strikingly, the loss of S6k1 in t...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-11 | PXD014832 | Pride
S6k1 Tsc1 Kidney Phosphoproteome Mtor 
TranscriptomicsScreen mRNAs specifically regulated by mTORC1 in colon epithelial cells from mice with dextran sulfate sodium (DSS)-induced experimental colitis
To screen mRNAs specifically regulated by mTORC1, a global mRNA expression profile in colon epithelial cells (CECs) from mice with or without CECs-specific TSC1 knockout (KO) was developed using microarray. Wile-type or CECs-specific TSC1 KO mice with experimental colitis were sacrificed, with CECs...
ORGANISM(S): Mus musculus 
2015-11-05 | E-GEOD-74674 | biostudies-arrayexpress
GenomicsTranscriptomic analysis of adipocyte Tsc1 knockout mammary glands.
Transcriptomic analysis of adipocyte Tsc1 knockout mammary glands.
PRJNA733105 | ENA
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