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ProteomicsComputational Prediction, Validation and Repurposing of Existing Drug as Inhibitor of Vascular Calcification
This study aimed to identify small molecules that inhibit vascular calcification with computational approach. To examine the mechanism of calcification inhibition, proteomics analysis was performed using aorta tissue samples to clarify therapeutic target.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD029963 | Pride
Vascular calcification Proteomics Mice Wnt signaling Drug discovery Drug repurposing 
TranscriptomicsmRNA expression profile in vascular smooth muscle cells (VSMCs) after inducing calcification
Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet to be elucidated. Here we report that MDM2-induced polyubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activi...
ORGANISM(S): Rattus norvegicus 
2015-11-07 | E-GEOD-74755 | biostudies-arrayexpress
TranscriptomicsThe effect of homocysteine on human aortic smooth muscle cells
Vascular calcification is a common manifestation of atherosclerosis and involves cell-mediated processes similar to the formation of bone (osteogenesis). Elevated plasma levels of homocysteine are an independent risk factor for atherosclerotic vascular disease but the underlying mechanisms remain un...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-9490 | biostudies-arrayexpress
ProteomicsProteomic characterization of extracellular vesicles (EVs) released by primary human vascular smooth muscle cells (VSMCs) under calcification stress
Vascular calcification (VC) is a strong predictor of cardiovascular risk, particularly in chronic kidney disease (CKD) patients, associated with increased vascular stiffness, pulse pressure, left ventricular hypertrophy and atherosclerotic plaque burden [1]. VC is currently accepted as a highly cont...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044045 | Pride
Human  vascular smooth muscle cells (vsmcs)  vascular calcification  lc-msms 
ProteomicsExtracellular Vesicles proteind in vascular calcification
Vascular Calcification (VC) is a life threatening cardiovascular complication that accounts for high death rates particularly in association with diabetes, atherosclerosis and Chronic Kidney Disease (CKD. during VC, Vascular Smooth Muscle Cells (VSMCs) undergo reprogramming into osteoblast-like cell...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-23 | PXD018169 | Pride
Type i collagen Extracellular vesicles Vascular calcification Oligogalacturonic acid 
TranscriptomicsDifferential miRNA expression in Cells and Matrix Vesicles in Vascular Smooth Muscle Cells from Rats with Kidney Disease
Vascular calcification is a complex process and has been associated with aging, diabetes, chronic kidney disease (CKD). Although there have been several studies studying the role of miRNAs (miRs) in bone osteogenesis, little is known about the role of miRs in vascular calcification and their role i...
ORGANISM(S): Rattus norvegicus 
2015-06-12 | E-GEOD-68913 | biostudies-arrayexpress
ProteomicsIndoxyl sulfate and p-cresyl sulfate directly promote vascular calcification via activation of inflammation and coagulation pathways
Vascular calcification contributes to high cardiovascular mortality in chronic kidney disease (CKD) patients. An association between the uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (PCS) and cardiovascular disease has been suggested. This study provides strong etiological evidence for in...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-06-13 | PXD012582 | Pride
Indoxyl sulfate Chronic kidney disease Vascular calcification Inflammation Hyperglycemia Coagulation P-cresyl sulfate Itraq-8plex 
ProteomicsThe Pharmacological Effect and Mechanism of Lanthanum Hydroxide on Vascular Calcification Caused by Chronic Renal Failure Hyperphosphatemia
Objective: To investigate the treatment and mechanism of lanthanum hydroxide on hyperphosphate-induced vascular calcification in chronic renal failure. Methods: Develop a rat model of CKD hyperphosphatemia. Rats were randomly allocated to the model, lanthanum hydroxide, lanthanum carbonate, Calcium...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-09 | PXD023081 | Pride
Hyperphosphatemia Vascular calcification Lanthanum hydroxide Mechanism Pharmacological effect Chronic renal failure 
GenomicsSTING facilitates vascular calcification via p-STAT1/NLRP3 signal
STING facilitates vascular calcification via p-STAT1/NLRP3 signal
PRJNA1187275 | ENA
ProteomicsCarnitine O-octanoyltransferase is a novel inducer of vascular calcification via promoting fatty acid metabolism and mitochondrial dysfunction
Objective – Vascular calcification is a critical pathology associated with increased cardiovascular event risk, but there are no FDA-approved anti-calcific therapies. We hypothesized and validated that an unbiased screening approach would identify novel mediators of human vascular calcification. Ap...
ORGANISM(S): Homo sapiens (Human) 
2021-02-26 | PXD022575 | Pride
Human primary smooth muscle cells Crot Cardiovascular calcification 
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