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ProteomicsAn ultra-high-resolution IonStar strategy enhancing accuracy and precision of MS1-based proteomics and an extensive comparison with state-of-the-art SWATH-MS in large-cohort quantification
Quantitative proteomics in large cohorts is highly valuable for biomedical/pharmaceutical investigations but often suffers from suboptimal reliability, accuracy, and reproducibility. Here we describe a new ultra-high-resolution (UHR) IonStar method achieving precise/reproducible protein measurement ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2021-06-24 | PXD017915 | Pride
Ultrahigh resolution ionstar 240k quantification 
ProteomicsA multi-species spike-in sample set for performance evaluation of label-free proteomics quantification
When evaluating the quantitative performance of label-free proteomics method(s), samples with known compositions are necessary to define key parameters such as reproducibility, missing data levels, accuracy, precision, as well as sensitivity/specificity for biomarker discovery. Here, we provide a ca...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2022-01-06 | PXD030780 | Pride
Performance evaluation Label-free quantification Ionstar 
UnknownHigh-quality and robust protein quantification in large clinical/pharmaceutical cohorts with IonStar proteomics investigation.
Not available
S-EPMC10673696 | biostudies-literature
ProteomicsHigh-quality and robust protein quantification in large clinical cohort of serum samples with IonStar
Robust, reliable quantification of large sample cohorts is often essential for meaningful clinical or pharmaceutical proteomics investigations, but it is technically challenging. When analyzing very large numbers of samples, isotope labeling approaches may suffer from substantial batch effects; and...
ORGANISM(S): Homo sapiens (Human) 
2023-10-12 | PXD036822 | Pride
Large-cohort clinical study  quantitative proteomics  ionstar  liquid chromatography-mass spectrometry  high-resolution mass spectrometry 
UnknownMass Defect-Based N,N-Dimethyl Leucine Labels for Quantitative Proteomics and Amine Metabolomics of Pancreatic Cancer Cells.
Not available
S-EPMC5338727 | biostudies-literature
ProteomicsAn ultra-high-resolution IonStar strategy enhancing accuracy and precision of MS1-based proteomics and an extensive comparison with state-of-the-art SWATH-MS in large-cohort quantification
Quantitative proteomics in large cohorts is highly valuable for biomedical/pharmaceutical investigations but often suffers from suboptimal reliability, accuracy, and reproducibility. Here we describe a new ultra-high-resolution (UHR) IonStar method achieving precise/reproducible protein measurement ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2021-06-24 | PXD017812 | Pride
Ultrahigh resolution ionstar Swath-ms 120k technical replicates 
ProteomicsAn ultra-high-resolution IonStar strategy enhancing accuracy and precision of MS1-based proteomics and an extensive comparison with state-of-the-art SWATH-MS in large-cohort quantification
Quantitative proteomics in large cohorts is highly valuable for biomedical/pharmaceutical investigations but often suffers from suboptimal reliability, accuracy, and reproducibility. Here we describe a new ultra-high-resolution (UHR) IonStar method achieving precise/reproducible protein measurement ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-24 | PXD017865 | Pride
Taxol-treated pancreatic cancer cells Ultrahigh resolution ionstar Swath-ms 
ProteomicsMulti-compartment quantitative proteomics revealing potential mechanisms underlying the treatment effects of mesenchymal-derived extracellular vesicles in a monkey model of cortical injury
Cortical injury frequently causes motor dysfunction, significantly impairing activities of daily living, and currently, there are no effective therapeutic options available. Previous studies demonstrated that intravenous infusion of mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) e...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2026-06-15 | PXD059286 | Pride
Mesenchymal stromal cell-derived extracellular vesicles Cortical injury Rhesus macaque Brain tissue Plasma Csf Lc-ms/ms 
ProteomicsEarly fallopian tube lesions and HGSC spatial proteomics dataset
High-grade serous carcinoma (HGSC) is the most common ovarian cancer subtype, typically diagnosed at late stages with poor prognosis. Understanding early molecular events driving HGSC progression is crucial for early-stage cancer detection and development of effective treatment stategies. We perform...
ORGANISM(S): Homo sapiens (Human) 
2026-09-29 | PXD084823 | Pride
Fallopian tube cancer precursors Ovarian cancer Spatial proteomics Hgsc Stic (serous tubal intraepithelial carcinoma) 
ProteomicsEarly fallopian tube lesions and HGSC multiomics dataset
High-grade serous cancer (HGSC) of the ovary is the most common ovarian cancer subtype, typically diagnosed at late stages with a poor prognosis. Understanding early molecular events driving HGSC progression is crucial for developing effective detection strategies. We integrated spatial cell-type re...
ORGANISM(S): Homo sapiens (Human) 
2026-09-22 | PXD062349 | Pride
Fallopian tube cancer precursors Ovarian cancer Spatial multiomics Hgsc 
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