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MetabolomicsLongitudinal Deep Multi-Omics Profiling in aCLN3Δex7/8Minipig Model Reveals Novel Biomarker Signatures for Batten Disease
Development of therapies for CLN3 Batten disease, a rare pediatric lysosomal storage disorder, has been hindered by the lack of etiological insights and translatable biomarkers to clinics. Here, we used a deep multi-omics approach to discover new biomarkers using longitudinal serum samples from a po...
2025-08-13 | MTBLS1107 | MetaboLights
ProteomicsMapping specificity, entropy, allosteric changes and substrates in blood coagulation proteases by a high-throughput protease screen
Proteases are crucial physiologic regulators of protein structure and function. While proteomic methods contributed extensively to protease characterization efforts, technical challenges remain in terms of throughput, scalability and large datasets of protease cleavages remain scarce. Here, we descr...
ORGANISM(S): Homo sapiens (Human) 
2021-02-05 | PXD018976 | Pride
High-throughput protease screen Substrates Blood coagulation proteases Specificity Entropy Allostery 
TranscriptomicsTranscriptional profiling of an HtrA proteases knock-out compared to wild type
Transcriptional profiling of an HtrA proteases knock-out compared to wild type on two different time points; logarithmic growth phase and stationary growth phase 3 Biological replicates per time point, two arrays
ORGANISM(S): Peptoclostridium difficile 
2014-08-02 | E-GEOD-55926 | biostudies-arrayexpress
ProteomicsHTPS screen of coagulation proteases at 20C with NaCl, ChCl, LiCl
Goal of the experiment is the characterization of proteases activity and specificity upon Na+ binding. Na+ is an allosteric binders that can induce a conformational change of the protease AS to regulate activity and specificity; only proteases with Y and F in position 225 can coordinate a Na+ molecu...
ORGANISM(S): Homo sapiens (Human) 
2021-02-04 | PXD022959 | Pride
Protease investigation 
TranscriptomicsCritical COPD respiratory illness is linked to increased transcriptomic activity of neutrophil proteases genes.
Abstract
BACKGROUND: Gene expression profiling (GEP) in cells obtained from peripheral blood has demonstrated to be a very useful approach for biomarker discovery and for studying molecular pathogenesis of prevalent diseases. While there is limited literature availble on gene expression markers a...
ORGANISM(S): Homo sapiens 
2013-03-12 | E-MEXP-3589 | biostudies-arrayexpress
ProteomicsProtease activity profiling of ovarian clear cell carcinoma
Ovarian clear cell carcinoma (OCCC) is an understudied poor prognosis subtype of ovarian cancer lacking in effective molecularly targeted therapies; efforts to define drivers of OCCC malignancy may lead to new therapeutic targets and approaches. Among potential targets are secreted proteases, enzyme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-07 | MSV000087385 | MassIVE
UnknownMembrane-anchored serine proteases as regulators of epithelial function.
Not available
S-EPMC9869603 | biostudies-literature
Proteomicsalpha-lytic proteases
S. pombe proteome digested separately by four proteases and analyzed with an LTQ-Orbitrap Velos with a data-dependent decision tree method.
2013-12-23 | MSV000078516 | MassIVE
OtherExecutioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart.
Data from PeptideAtlas, [[http://www.peptideatlas.org/PASS/PASS00689 PASS00689]]. File: JAL_DanSanc_Hrt_iTRAQ_Fr6.mzml. Published as part of PLoS One. 2015 Jun 29;10(6):e0131411 . From the Abstract: {{i}} Executioner caspase-3 and -7 are proteases promoting cell death but non-apoptotic roles are be...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320017677 | GPMDB
GenomicsPeptide gene sequences of substrate phage for different proteases
Peptide gene sequences of substrate phage for different proteases
PRJNA647886 | ENA
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