Sort   by:  
 Page size 
ProteomicsScaffold-free 3D cell culture of primary skin fibroblasts induces profound changes of the matrisome
We analyze the effect of magnetic 3D bioprinting using NanoShuttle-PL on the proteome of primary human skin fibroblasts and epidermal squamous cell carcinoma cells. NanoStuttle-PL employs magnetic nanoparticles that interact electrostatically with cells rendering them magnetic and allowing manipulat...
ORGANISM(S): Homo sapiens (Human) 
2021-07-16 | PXD023701 | Pride
Skin Fibroblast Nanoshuttle Human 
TranscriptomicsMicroarray of reconstructed epidermis from skin models made with cells from African and Caucasian Skin type
The aim of this study was to analyze the in vitro biological epidermal processes occurring in reconstructed skins using cells from breast skin of African and Caucasian skin type color. A exploration of mRNA expression levels in the epidermis of reconstructed skin was undertaken to elucidate the diff...
ORGANISM(S): Homo sapiens 
2020-08-10 | E-MTAB-9433 | biostudies-arrayexpress
TranscriptomicsMurine skin gene expression analysis of skin-specific Scd1-deficient and control mice
To help elucidate the metabolic changes in the skin that contribute to the obesity resistance and skin pathology in mice lacking Scd1, we performed microarray analysis of skin gene expression in male skin Scd1 knockout (SKO) and Scd1 flox/flox control (Lox) mice fed a standard rodent diet. We identi...
ORGANISM(S): Mus musculus 
2011-05-09 | E-GEOD-24243 | biostudies-arrayexpress
ProteomicsThe human pathobiont Malassezia furfur secreted protease MfSAP1 regulates cell dispersal and exacerbates skin inflammation
Malassezia forms the dominant eukaryotic microbial community on the human skin. The Malassezia genus possesses a repertoire of secretory hydrolytic enzymes involved in protein and lipid metabolism which alter the external cutaneous environment. The exact role of most Malassezia secreted enzymes, inc...
ORGANISM(S): Cellular Organisms 
2022-11-11 | PXD033336 | JPOST Repository
TranscriptomicsTranscription profiling of human skin during elicitation of allergic contact dermatitis - time series
Genes involved in the inflammatory response resulting in allergic contact dermatitis (ACD) are only partly known. In this study, we introduce the use of high density oligonucleotide arrays for gene expression profiling in human skin during the elicitation of ACD. Skin biopsies from normal and nickel...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6281 | biostudies-arrayexpress
ProteomicsSynergistic effects between rutin and ascorbic acid in the protection of the proteome of 3D-cultured human skin fibroblasts from UVA radiation
This study demonstrates the cooperation of rutin and ascorbic acid in cytoprotective action against UVA induced changes in the context of proteins involved in gene expression, catalytic processes, antioxidant pathways, as well as signalling molecules including transmembrane channels. The main advant...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD018730 | Pride
Skin fibroblasts  uva radiation  rutin  ascorbic acid  proteomics  3d cell culture 
TranscriptomicsTranscriptomic analysis of human skin Langerhans cell and dermal dendritic cells stimulated in vitro with TNF-alpha
Langerhans cells (LCs) are antigen presenting cells residing in the epidermis. Due to the difficulties with obtaining sufficient quantities of LCs for functional studies, many controversies exist about their origin and function. To gain insights into the molecular mechanisms underpinning LC biology ...
ORGANISM(S): Homo sapiens 
2013-12-08 | E-GEOD-49475 | biostudies-arrayexpress
TranscriptomicsExpression data from human 3D skin models in response to IL-31 treatment
Atopic dermatitis, a chronic inflammatory skin disease with increasing prevalance, is closely associated with skin barrier defects. A cytokine related to disease severity and inhibition of keratinocyte differentiation is IL-31. To identify its molecular targets, IL-31-dependent gene expression was d...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-76880 | biostudies-arrayexpress
ProteomicsQuantitative LC-MS/MS Proteomics of human skin and LabSkin model
We report for the first time label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases and nucleases in six human skin explants and a 3D living skin equivalent model from LabSkin. More than 2000 proteins were identified and quantified from total cell...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD020742 | Pride
Human Skin Labskin Lc-ms/ms 
TranscriptomicsTranscription profiling of mouse tendon, cornea, and skin fibroblasts stimulated with mechanical stress to test the hypothesis that fibroblasts from different tissues are phenotypically distinct from one another.
In order to test the hypothesis that fibroblasts from different tissues are phenotypically distinct from one another, we have subjected tendon, skin and corneal fibroblasts of fetal mouse to mechanical stimulation by fluid flow and analyzed the transcriptional responses of the cells using Affymetrix...
ORGANISM(S): Mus musculus 
2007-10-12 | E-GEOD-3486 | biostudies-arrayexpress
Sort   by:  
 Page size