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TranscriptomicsCross-talk between 4-1BB and TLR1-TLR2 signaling in CD8+ T cells regulates TLR2’s costimulatory effects
The activation of TLR-MyD88 (Toll like receptor- Myeloid differentiation factor 88) signaling within T cells functions as a potent costimulatory signal that boosts antitumor and antiviral responses. However, the molecular mechanisms underlying the costimulatory processes are poorly understood. We co...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-79475 | biostudies-arrayexpress
GenomicsRNA-seq of murine 4-1BB- and 4-1BB+ CD8+ tumor-infiltrating T cells in HCC patients
RNA-seq of murine 4-1BB- and 4-1BB+ CD8+ tumor-infiltrating T cells in HCC patients
PRJNA1104295 | ENA
ProteomicsCD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects
CD137 (4-1BB) is a member of the TNFR family that mediates potent T-cell costimulatory signals upon ligation by CD137L or agonist monoclonal antibodies. CD137 agonists attain immunotherapeutic antitumor effects in cancer mouse models and multiple agents of this kind are undergoing clinical trials. W...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042585 | Pride
4-1bb Smac mimetic compounds Cd137 Ciap1 Ciap2 Immunotherapy 
GenomicsTime-dependent enhancement of mRNA vaccines by 4-1BB costimulatory antibodies
Time-dependent enhancement of mRNA vaccines by 4-1BB costimulatory antibodies
PRJNA1083572 | ENA
Genomics4-1BB overexpression in basal keratinocytes induces the disruption of the eye's immune privilege
4-1BB overexpression in basal keratinocytes induces the disruption of the eye's immune privilege
PRJNA507179 | ENA
GenomicsGene expression profiles of 4-1BB+PD-1-high, 4-1BB-PD-1-high, and PD-1-int tumor-infiltrating CD8 T cells in hepatocellular carcinoma
Gene expression profiles of 4-1BB+PD-1-high, 4-1BB-PD-1-high, and PD-1-int tumor-infiltrating CD8 T cells in hepatocellular carcinoma
PRJNA549151 | ENA
Genomics4-1BB causes CAR-T cell death via sequestration of the ubiquitin-modifying enzyme A20
4-1BB causes CAR-T cell death via sequestration of the ubiquitin-modifying enzyme A20
PRJNA1113315 | ENA
GenomicsEffect of CD137 (4-1BB) triggering on human monocytes
Effect of CD137 (4-1BB) triggering on human monocytes
PRJNA718345 | ENA
GenomicsGene expression in self-activating CAR-T cells with CD28 or 4-1BB costimulatory domains.
Gene expression in self-activating CAR-T cells with CD28 or 4-1BB costimulatory domains.
PRJNA965890 | ENA
TranscriptomicsRNA-seq of murine 4-1BB- and 4-1BB+ CD8+ tumor-infiltrating T cells in HCC patients
We aimed to analyze the transcriptomic differences in CD8+ tumor-infiltrating T cells according to 4-1BB expression in HCC
ORGANISM(S): Homo sapiens 
2024-04-30 | GSE265834 | GEO
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