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ProteomicsCD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects
CD137 (4-1BB) is a member of the TNFR family that mediates potent T-cell costimulatory signals upon ligation by CD137L or agonist monoclonal antibodies. CD137 agonists attain immunotherapeutic antitumor effects in cancer mouse models and multiple agents of this kind are undergoing clinical trials. W...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042585 | Pride
4-1bb Smac mimetic compounds Cd137 Ciap1 Ciap2 Immunotherapy 
TranscriptomicsTranscriptional and functional characterization of dendritic cell differentiation induced by CD137 ligand reverse signaling in human monocytes
The contribution of monocyte-derived dendritic cells (DC) to an immune response is essential for the elimination of pathogens. In vitro DC can be generated by treatment of monocytes with GM-CSF + IL-4 but it is unknown what stimuli induce the differentiation of monocytes to DC in vivo. CD137L-DC are...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-60199 | biostudies-arrayexpress
GenomicsCD137-CIS IO
CD137-CIS IO
PRJNA663842 | ENA
TranscriptomicsAntigen specific human conventional T cells (CD154+) or regulatory T cells (CD137+) directed agains A. fumigatus or Birch pollen lysate isolated from Birch pollen allergic patients or healthy controls.
Foxp3+ regulatory T cells (Treg) play a central role for tolerance against self and innocuous environmental antigens. However, the role of antigen-specificity for Treg-mediated tolerance is only incompletely understood. Here we show by direct ex vivo characterization of human CD4+ T cells, that the ...
ORGANISM(S): Homo sapiens 
2016-10-25 | E-GEOD-77018 | biostudies-arrayexpress
GenomicsEffect of CD137 (4-1BB) triggering on human monocytes
Effect of CD137 (4-1BB) triggering on human monocytes
PRJNA718345 | ENA
GenomicsAnti-CD137 drives early epigenetic remodeling of Tex cell associated genes
Anti-CD137 drives early epigenetic remodeling of Tex cell associated genes
PRJNA949175 | ENA
GenomicsDifferentiated agonistic antibody targeting CD137 eradicates large tumors without hepatotoxicity
Differentiated agonistic antibody targeting CD137 eradicates large tumors without hepatotoxicity
PRJNA603752 | ENA
TranscriptomicsCD137-CIS IO
CD137 cis-costimulation is superior to trans-costimulation at inducing transcriptomic differences in T-cell proliferation and DNA repair programs We used microarrays to detail differentially expressed genes of cis- and trans CD137-costimulated CD8 T cells with respect to CD3-TCR stimulation
ORGANISM(S): Homo sapiens 
2021-09-28 | GSE158041 | GEO
UnknownSoluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies.
Not available
S-EPMC8896037 | biostudies-literature
UnknownRegulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis.
Not available
S-EPMC7914903 | biostudies-literature
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