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MetabolomicsDisruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Mouse Model of Amyloidosis
Alzheimer’s disease (AD) is characterized by a prolonged asymptomatic phase before cognitive decline emerges, yet the mechanisms driving symptom onset remain unclear. Here, we hypothesized that the transition from asymptomatic to symptomatic disease is linked to dysfunction of brain–immune communica...
2026-06-01 | MTBLS14615 | MetaboLights
TranscriptomicsAlzheimer's model and vitamin D
Little is known about the global molecular changes leading to neurodegeneration and brain dysfunction in Alzheimer's disease (AD). To study the molecular cascades involved, we chose to study the transcriptomic profile of an early-onset AD model, the 5xFAD mice, at different time points (1 month, 4 m...
ORGANISM(S): Mus musculus 
2014-04-30 | E-MTAB-1937 | biostudies-arrayexpress
TranscriptomicsExpression data from WT and TREM2 deficient microglia in a mouse model of Alzheimer's disease
We examined the role of TREM2 on microglia responses to amyloid-beta deposition in a mouse model of Alzheimer's disease Microglia were FACS-purified from 8.5 month old WT, Trem2-/-, 5XFAD, and Trem2-/- 5XFAD mice
ORGANISM(S): Mus musculus 
2015-03-13 | E-GEOD-65067 | biostudies-arrayexpress
Proteomics5xFAD transgenic mouse Abeta proteoforms
In this study, we have evaluated amyloidosis-relevant Aβ proteoform flux using immunoenrichment and quantitative Top-Down Mass Spectrometry in a well-studied 5xFAD mouse model of age-dependent Aβ amyloidosis.
ORGANISM(S): Mus musculus (Mouse) 
2023-09-27 | PXD042921 | Pride
Amyloid beta Alzheimer’s disease Transgenic mouse model 5xfad Top-down mass spectrometry 
ProteomicsA proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimers disease
State-of-the-art mass spectrometry (MS) methods can comprehensively detect proteomic alterations in neurodegenerative disorders, providing relevant insights unobtainable with transcriptomics investigations. Analyses of the relationship between progressive aggregation and protein abundance changes in...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-21 | PXD030348 | Pride
Mouse model Amyloidogenesis Proteomics Alzheimers disease 5xfad 
ProteomicsComprehensive Proteomic Profiling of Urinary Exosomes and Identification of Potential Noninvasive Early Biomarkers of Alzheimer’s Disease in 5XFAD Mouse Model
To investigate the potential noninvasive early biomarkers of AD in 5XFAD mouse model, we investigate the proteome of urinary exosomes present in 1-month-old (before amyloid-β accumulation) 5XFAD mouse models and their littermate controls. Another two groups of 2 and 6 months-old urinary samples were...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021935 | Pride
Urinary exosome proteome Alzheimer’s disease 5xfad mouse model Early diagnosis Biomarkers 
ProteomicsQuantitative proteomics of CSF from the Alzheimer's disease mouse model 5xFAD
The 5xFAD mouse model was used to study the influence of amyloid pathology on the cerebrospinal fluid (CSF) proteome. Therefore, CSF of 7-months old 5xFAD and WT control mice was sampled with an improved collection protocol. Using a minute amount of 5 µL CSF, we applied data dependent and data indep...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-15 | PXD053568 | Pride
Cerebrospinal fluid Dia 5xfad Alzheimer's disease Csf Dda 
ProteomicsDeep proteome profiling of hippocampus in 5xFAD mouse model
Alzheimer's disease (AD) is the most common neurodegenerative disease and characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tangles. Although extensive research was performed for Alzheimer's disease (AD) is the most common neurodegenerative disease an...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD012238 | Pride
Hippocampus 5xfad Label-free quantification 
TranscriptomicsTranscriptomic effects of long-term pantethine treatment in the mouse Alzheimer's disease 5XFAD model
Pantethine, an anti-cholesterol drug, was shown to inhibit the Ab (amyloid beta) peptide-induced expression of IL-1b in primary culture astrocytes derived from either untreated Ab-treated and untreated 5XFAD or Ab-treated WT. These observations prompted us to investigate the effects of pantethine at...
ORGANISM(S): Mus musculus 
2018-07-15 | E-MTAB-6772 | biostudies-arrayexpress
ProteomicsHippocampal disruptions of synaptic and astrocyte metabolism during early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is an unremitting neurodegenerative disorder characterized by cerebral amyloid-β (Aβ) accumulation and gradual decline in cognitive function. Changes in brain energy metabolism arise in the preclinical phase of AD, suggesting an important metabolic component of early AD path...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-09 | PXD025240 | Pride
Synaptosomes Hippocampus Ad Brain energy metabolism Seahorse Mitochondria Glucose Cerebral cortex 
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