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ProteomicsHepatoprotective effect of picroside I on thioacetamide-induced hepatic fibrosis determined by proteomic analyses
We explored whether and how picroside I protects against TAA-induced liver fibrosis in mice through proteomic analysis of the liver. The proteomic studies were conducted based on liquid-chromatography coupled with tandem mass spectrometry.Importantly,the iTRAQ 8plex reagent kits were used for protei...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-30 | PXD014150 | Pride
Lc-msms Mouse Liver 
ProteomicsTime-resolved substrate degradomics
20110318_GluC: Cell culture supernatants from Balb/c 3T3 mouse fibroblasts that had been incubated with the endoproteinase GluC (Staphylococcus aureus protease V8) as test protease for 1, 2, 4, 8, and 16 hours or buffer alone (0, 12, and 16 hours controls) were subjected to 8plex-iTRAQ-TAILS analys...
ORGANISM(S): Mus musculus (Mouse) 
2013-12-13 | PXD000503 | Pride
Protease 8plex-itraq Tails Kinetics Mmp 
ProteomicsGerm-free mouse ileum iTRAQ shotgun LC-MSMS
Shotgun proteomics of normal versus germ-free mouse terminal ileum. 39 mice. Male and female. BALBc and C57BL10. The samples were labeled using iTRAQ 8plex and analyzed using a nano-LC-LTQ-Orbitrap-Velos-MSMS. This is the proteomics data from an n-omics project.
ORGANISM(S): Mus musculus (Mouse) 
2017-10-04 | PXD003177 | Pride
Lc-msms Germ-free Mouse Itraq Orbitrap Ileum 
ProteomicsCharacterization of gastric tumor organoids with specific oncogenic pathway activations
Gastric cancer ranks the fifth most common malignancy and the third leading cause of cancer related death worldwide. Classical chemotherapy is still the standard treatment in advanced stages, with only two targeted therapies currently in clinical use. Several targeted trials have failed, likely due ...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-22 | PXD022015 | Pride
Phospho proteome signature Proteome signature Murine tumor organoid models Gastric cancer 
ProteomicsLocalised protein expression changes in different regions of human Alzheimer’s brain correlate with disease severity - Entorhinal cortec
Human brain tissue was obtained from the New Zealand Brain Bank from donors with Alzheimer's disease (AD) or age-matched controls (n=9/group). Mean post mortem delays were ~12h. Six distinct brain regions were dissected, Hippocampus, Cingulate Gyrus, Entorhinal Cortex (severely affected), Motor and ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD008806 | Pride
Human Dementia Brain Alzheimer’s Entorhinal cortex Itraq 
ProteomicsLocalised protein expression changes in different regions of human Alzheimer’s brain correlate with disease severity - Entorhinal Cortex
Human brain tissue was obtained from the New Zealand Brain Bank from donors with Alzheimer's disease (AD) or age-matched controls (n=9/group). Mean post mortem delays were ~12h. Six distinct brain regions were dissected, Hippocampus, Cingulate Gyrus, Entorhinal Cortex (severely affected), Motor and ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD008765 | Pride
Human Dementia Brain Entorhinal cortex Alzheimer’s Itraq 
ProteomicsLocalised protein expression changes in different regions of human Alzheimer’s brain correlate with disease severity - Sensory Cortex
Alzheimer's disease (AD) or age-matched controls (n=9/group). Mean post mortem delays were ~12h. Six distinct brain regions were dissected, Hippocampus, Cingulate Gyrus, Entorhinal Cortex (severely affected), Motor and Sensory Cortex (less affected) and Cerebellum (spared). Protein was extracted fro...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD008753 | Pride
Human Dementia Brain Sensory cortex Alzheimer’s Itraq 
ProteomicsLocalised protein expression changes in different regions of human Alzheimer’s brain correlate with disease severity - Cerebellum
Human brain tissue was obtained from the New Zealand Brain Bank from donors with Alzheimer's disease (AD) or age-matched controls (n=9/group). Mean post mortem delays were ~12h. Six distinct brain regions were dissected, Hippocampus, Cingulate Gyrus, Entorhinal Cortex (severely affected), Motor and ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD008755 | Pride
Human Dementia Brain Cerebellum Alzheimer’s Itraq 
ProteomicsLocalised protein expression changes in different regions of human Alzheimer’s brain correlate with disease severity - Cingulate Gyrus
Human brain tissue was obtained from the New Zealand Brain Bank from donors with Alzheimer's disease (AD) or age-matched controls (n=9/group). Mean post mortem delays were ~12h. Six distinct brain regions were dissected, Hippocampus, Cingulate Gyrus, Entorhinal Cortex (severely affected), Motor and ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD008779 | Pride
Human Dementia Brain Alzheimer’s Cingulate gyrus Itraq 
ProteomicsAge-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy
To gain understanding on the mechanisms that drive immunosenescence in humans, we examined CD4+ T cells obtained from younger (20-39 years-old) and older (70+ years-old) healthy participants of the Baltimore Longitudinal Study on Aging (BLSA). We found that mitochondrial proteins involved in the el...
ORGANISM(S): Homo sapiens (Human) 
2019-11-27 | PXD016039 | Pride
Autophagy Proteomics Mitochondria Cd4+ t cells Aging 
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