A histone demethylase

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2012 (77)
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CHEBI ID

CHEBI:28393 (1)
CHEBI:14434 (1)
CHEBI:166843 (1)
CHEBI:33283 (1)
CHEBI:2086 (1)
CHEBI:89582 (1)
CHEBI:37023 (1)
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CHEBI:16946 (1)
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CHEBI:46229 (1)
CHEBI:16238 (1)

Metabolite Name

Adenosine (2)
Deoxyadenosine monophosphate (dAMP) (1)
Deoxycytidine monophosphate (dCMP) (1)
NG,NG-Dimethyl-L-arginine (ADMA) (1)
Dihydroxy-acetone-phosphate (1)
Thiamine monophosphate (TMP) (1)
FA 18:4+1O (1)
Deoxyguanosine triphosphate (dGTP) (1)
Beta-D-Glucosamine (1)
2'-Deoxyguanosine 5'-monophosphate (dGMP) (1)
Imidazole (1)
Riboflavin (Vitamin B2) (1)
Gamma-Glutamyl-L-methionine (1)
7-methylguanosine (1)
N-ACETYL-DL-SERINE (1)
Adenosine 5'-diphosphate (1)
Uridine diphosphate glucose (UDP-D-Glucose) (1)
Gamma-L-Glutamyl-L-valine (1)
Gamma-L-Glutamyl-L-phenylalanine (1)
LysoPE(16:0/0:0) (1)
Inosine 5'-monophosphate (IMP) (1)
Nicotinic acid (1)
Ureidopropionic acid (1)
Cytidine 5'-monophosphate (CMP) (1)
LysoPE(18:0/0:0) (1)
Histamine (1)
Nicotinamide adenine dinucleotide (NAD) (1)
L-Carnosine (1)
Folic acid (1)
5-Methoxydimethyltryptamine (1)

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Classification

protozoa (6)
fungi (4)

Modification

N6 (2)
N6-dimethyl-L-lysine (1)

Study status

Not provided (1)

Study type

Transcription profiling by array (152)
ChIP-seq (118)
RNA-seq of coding RNA (81)
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1999 (1)

Lab affiliation

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, 75390, TX, USA (2)
The University of South Florida (1)
1Department of Biochemistry and Biophysics, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States (1)
Università degli Studi della Campania Luigi Vanvitelli (1)
Department of Biomedical Science E-04, Florey building Firth Court, Western Bank University of Sheffield Sheffield, S10 2TN United Kingdom (1)
Dr. Eric U. Selker Institute of Molecular Biology University of Oregon Eugene, Oregon 97403, USA (1)
Department of Biotechnology, TU Delft, NL (1)
Institut Pasteur, Université de Paris, UMR3691 CNRS, Unité de Biologie cellulaire de l'infection microbienne, F-75015, Paris, France. (1)
Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), 1030 Vienna, Austria. (1)
Department of Plant Biology, Carnegie Instition for Science (1)
Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland (1)
Università Luigi Vanvitelli (1)
Centre for medicines discovery, University of Oxford (1)
University of Wisconsin-Madison, Cellular and Regenerative Medicine (1)
Department of Microbiology and Molecular Genetics University of Pittsburgh (1)
Aarhus University Institute of Molecular Biology and Genetics Universitetsbyen 81 8000 Aarhus Denmark (1)
European Instutute of Oncology (1)
Department of Molecular Integrative Physiology University of Illinois at Urbana/Champaign Urbana, IL 61801 (1)
WCCB, University of Edinburgh (1)
Department of Molecular Genetics (190g), University of Hohenheim (1)
Biological Mass Spectrometry Lab, Department of Translational Medicine (DiMeT), Center for Translational Research on Autoimmune & Allergic Diseases - CAAD, University of Piemonte Orientale, Novara, Italy (1)
Sun Yat-Sen University (1)
The University of Tokyo (1)
Department of Biological Sciences, Vanderbilt University (1)
Department of Structural and Molecular Biology IBMB-CSIC Barcelona, Spain (1)
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia (1)
China (1)
Kidney and Dialysis Institute of Shanghai (1)
Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy (1)
Institute for Research in Biomedicine, Baldiri i Reixac 10, Barcelona 08028, Spain (1)

Location

United Kingdom (1)

Keyword

Domatinostat (1)
Bavencio (1)

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Histone H3K4me3 Demethylase RBP2 Transcriptionally Activates PPARγ to Drive Lipid Metabolic Reprogramming in Gastric Carcinoma

This work investigates epigenetic driven lipid metabolic reprogramming in gastric carcinoma. We characterize that histone H3K4me3 demethylase RBP2 transcriptionally activates PPARgama by binding to its promoter region,thereby promoting lipogenic gene expression and intracellular lipid accumulatio...

2026-08-14 | MTBLS15324 | MetaboLights

CpG islands recruit a histone H3 lysine 36 demethylase

This SuperSeries is composed of the following subset Series: GSE18588: CpG islands recruit a histone H3 lysine 36 demethylase [Illumina sequencing data] GSE21201: CpG islands recruit a histone H3 lysine 36 demethylase [Agilent data] Refer to individual Series

ORGANISM(S): Homo sapiens

2010-04-26 | E-GEOD-21202 | biostudies-arrayexpress

Histone Demethylase Lsd1 is Required to Repress Hematopoietic Stem and Progenitor Cell Signatures During Blood Cell Maturation

Here we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on LysM-bM-^@M-^I4 or LysM-bM-^@M-^I9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis in primary hematopoietic cells, combining global occ...

ORGANISM(S): Mus musculus

2013-06-25 | E-GEOD-40440 | biostudies-arrayexpress

The S. cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2

Histone methylation plays important roles in the regulation of chromatin dynamics and transcription. Steady state levels of histone lysine methylation are regulated by a balance between enzymes that catalyze either the addition or removal of methyl groups. Using an activity-based biochemical approac...

ORGANISM(S): Saccharomyces cerevisiae

2010-06-11 | E-GEOD-7627 | biostudies-arrayexpress

CpG islands recruit a histone H3 lysine 36 demethylase [Illumina sequencing data]

Eukaryotic gene expression profiles are largely defined by transcription factors that recognize specific DNA sequences in gene regulatory regions and impact RNA polymerase recruitment and transcription. In addition to specific core promoter regulatory elements, up to 70% of genes in higher eukaryote...

ORGANISM(S): Mus musculus

2010-04-27 | E-GEOD-18588 | biostudies-arrayexpress

The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation

Here we show that T-box proteins team up with chromatin modifying enzymes to drive the expression of the key lineage regulator, Eomes during endodermal differentiation of embryonic stem (ES) cells. The Eomes locus is maintained in a transcriptionally poised configuration in ES cells. During early di...

ORGANISM(S): Mus musculus

2013-04-18 | E-GEOD-44764 | biostudies-arrayexpress

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

This SuperSeries is composed of the following subset Series: GSE34672: Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [Illumina HumanHT-12 gene expression array] GSE34725: Inhibition of the LSD1 (KDM1A) demethylase...

ORGANISM(S): Homo sapiens

2012-03-14 | E-GEOD-34726 | biostudies-arrayexpress

OsJMJ703, a Histone H3K4 Demethylase, Controls Transposon Activity in Rice

Retrotransposons are classified into long terminal repeat (LTR) or non-LTR retrotransoposons, and both types can mobilize in a “copy and paste” manner. Rice genome contains >40% of repetitive sequences or transposable elements (TEs) that scattered throughout the genome. TE activities are tightly reg...

ORGANISM(S): Oryza sativa Japonica Group

2013-01-01 | E-GEOD-41183 | biostudies-arrayexpress

Genome-wide map of lysine specific demethylase 1 (LSD1) in mouse embryonic stem cells.

We report the identification of LSD1 binding genomic regions in mouse embryonic stem cells (ESC) by high throughput sequencing. By obtaining over 10 million 36 bp reads of sequence from each chromatin immunoprecipitated DNA, we generated genome-wide maps for LSD1 and histone H3 dimethylated on lysin...

ORGANISM(S): Mus musculus

2012-10-03 | E-GEOD-18515 | biostudies-arrayexpress

Phosphorylation of methyltransferase Set2p and demethylase Jhd1p and its association with histone H3K36 methylation and stress response pathways in Saccharomyces cerevisiae

Histone lysine methylation is a key epigenetic modification that regulates eukaryotic transcription. In Saccharomyces cerevisiae, it is controlled by a reduced but evolutionarily conserved suite of methyltransferase (Set1p, Set2p, Dot1p, and Set5p) and demethylase (Jhd1p, Jhd2p, Rph1p, and Gis1p) en...

ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast)

2022-03-07 | PXD029088 | Pride

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