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Mutations in the RNA splicing factor gene SF3B1 are common across hematologic and solid cancers and result in widespread alterations in splicing, but therapeutic means to correct this mis-splicing do not exist. Here, we utilize synthetic introns uniquely responsive to mutant SF3B1 to identify trans ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD044973 | Pride
Here we interrogate CD32A protein interactions in the cytoplasm and membrane fractions isolated from the human AML cell lines K562 wild-type and knockout for CD32A. Cells were fractionated prior to incubation with CD32A antibody and subsequent samples isolated using protein agarose beads.
ORGANISM(S): Homo sapiens (Human) 
2023-09-05 | PXD042514 | Pride
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