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ProteomicsActivity-based profiling of deubiquitylating enzymes
This set is a repackaging of PXD031848 (described in https://doi.org/10.3390/ijms23063263: "ABPP-HT*-Deep Meets Fast for Activity-Based Profiling of Deubiquitylating Enzymes Using Advanced DIA Mass Spectrometry Methods") to make each LC-MS/MS experiment individually downloadable and to include TIMSC...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-07-24 | MSV000095426 | MassIVE
UnknownIdentification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA.
Not available
S-EPMC9195458 | biostudies-literature
ProteomicsQuantitative Chemoproteomic Profiling with Data-Independent Acquisition-based Mass Spectrometry
Activity-based protein profiling (ABPP) has emerged as a powerful and versatile tool to enable annotation of protein functions and discovery of targets of bioactive ligands in complex biological systems. It utilizes chemical probes to covalently label functional sites in proteins so that they can be...
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-07-27 | PXD027578 |
ProteomicsActivity-based SWATH/DIA proteomic screen enables sensitive differential detection of serine hydrolases from surgically resected OCT-embedded primary lung adenocarcinoma
Lung malignancies are among the leading causes of cancer-related death in the modern world. While the disease is relatively manageable if caught at an early stage, the genomic variability and high level of mutations represent a daunting challenge for diagnosis, staging and prognostic classification....
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD019357 | Pride
Abpp Lung adenocarcinoma tissue Swath-ms 
ProteomicsABPP-HT* - Deep meets fast for activity-based profiling of deubiquitylating enzymes using advanced DIA mass spectrometry methodsABPP-HT* - Deep meets fast for activity-based profiling of deubiquitylating enzymes using advanced DIA mass spectrometry methods
Activity-based protein profiling (ABPP) uses a combination of activity-based chemical probes with mass spectrometry (MS) to selectively characterise a particular enzyme or enzyme class. ABPP has proven invaluable for profiling enzymatic inhibitors in drug discovery. When applied to cell extracts and...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD031848 | Pride
Data-independent acquisition mass spectrometry (dia) Drug discovery Proteomics Activitomics Mass spectrometry Chemical biology Deubiquitylating enzymes Ubiquitin Activity-based probes 
UnknownHigh-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils.
Not available
S-EPMC7073015 | biostudies-literature
UnknownABPP-HT*-Deep Meets Fast for Activity-Based Profiling of Deubiquitylating Enzymes Using Advanced DIA Mass Spectrometry Methods.
Not available
S-EPMC8955990 | biostudies-literature
ProteomicsComparison of Targeted MS Methods in Activity-Based Protein Profiling 1: DDA
To examine the different mass spectrometry approaches to monitoring kinases after enrichment with desthiobiotinylating probes for activity-based protein profiling (ABPP), two experiments were performed with H1993 lung cancer cells. First, cell lysates were pre-treated with DMSO vehicle, dasatinib, ...
ORGANISM(S): Homo sapiens (Human) 
2017-11-27 | PXD006095 | Pride
Dda Activity-based protein profiling Dia Prm Srm/mrm Lung cancer 
ProteomicsComparison of Targeted MS Methods in Activity-Based Protein Profiling 2: DIA
To examine the different mass spectrometry approaches to monitoring kinases after enrichment with desthiobiotinylating probes for activity-based protein profiling (ABPP), two experiments were performed with H1993 lung cancer cells. First, cell lysates were pre-treated with DMSO vehicle, dasatinib, ...
ORGANISM(S): Homo sapiens (Human) 
2017-11-27 | PXD006096 | Pride
Dda Activity-based protein profiling Dia Prm Srm/mrm Lung cancer 
UnknownProteomic characterization of serine hydrolase activity and composition in normal urine.
Not available
S-EPMC4225696 | biostudies-literature
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