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TranscriptomicsIdentification of the alternative sigma factor SigX regulon and its implications for Pseudomonas aeruginosa pathogenicity
We analyzed a deletion mutant of the ECF M-OM-^C factor SigX and applied mRNA profiling to define the SigX dependent regulon in P. aeruginosa in response to low osmolarity medium conditions. Furthermore, the combination of transcriptional data with chromatin immunoprecipitation (ChIP) followed by hi...
ORGANISM(S): Pseudomonas aeruginosa UCBPP-PA14 
2013-11-11 | E-GEOD-50937 | biostudies-arrayexpress
UnknownPassive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: prospective cohort study.
Not available
S-EPMC8264915 | biostudies-literature
UnknownPassive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: Prospective cohort study.
Not available
S-EPMC8109203 | biostudies-literature
MetabolomicsThe Kalanchoe genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism
Crassulacean acid metabolism (CAM) is a water-use efficient adaptation of photosynthesis that has evolved independently many times in diverse lineages of flowering plants. We hypothesize that convergent evolution of protein sequence and temporal gene expression underpins the independent emergences o...
2018-01-09 | MTBLS519 | MetaboLights
TranscriptomicsGenome-wide screen reveals rhythmic regulation of genes involved in odor processing in the olfactory epithelium
Odor discrimination behavior displays circadian fluctuations in mice indicating that mammalian olfactory function is under control of the circadian system. This is further supported by the facts that odor discrimination rhythms depend on the presence of clock genes and that olfactory tissues contain...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-69853 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mature, naive B cells to investigate how the PTPN22 autoimmune susceptibility gene affects the removal of human developing autoreactive B cells.
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene segregates with most autoimmune diseases; its risk allele encodes overactive PTPN22 phosphatases that alter B cell receptor (BCR) signaling potentially involved in the regulation of central B cell tolerance. To assess whether PTPN22 ris...
ORGANISM(S): Homo sapiens 
2010-10-16 | E-GEOD-24736 | biostudies-arrayexpress
GenomicsNIDDK IBD Genetics Consortium Crohn's Disease Genome-Wide Association Study

This dataset contains data from a genome-wide association study performed with 968 Inflammatory Bowel Disease (IBD) affected cases and 995 unrelated controls using the Illumina HumanHap300 Genotyping BeadChip. Cases were selected to have Crohn's disease with ileal involvement, and con...

phs000130.v1.p1 | EGA
GenomicsGenome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types
We report genome-wide characterization of GATA3 binding sites in eleven well-defined developmental and effector cell types of the T lymphocyte lineage. By utilizing a conditional allele of GATA3, we investigated the impact of GATA3 expression on the mRNA expression patterns in several of these cell...
ORGANISM(S): Mus musculus 
2011-08-26 | E-GEOD-20898 | biostudies-arrayexpress
TranscriptomicsGene expression profiling: human CD8+CD45RO+ memory T cells in IL23 responsive and nonresponsive individuals
The interleukin-23 (IL-23) pathway plays a critical role in the pathogenesis of multiple chronic inflammatory disorders, however, inter-individual variability in IL-23-induced signal transduction in circulating human lymphocytes has not been well-defined. In this study, we observed marked, reproduci...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-42051 | biostudies-arrayexpress
TranscriptomicsToxicogenomic Study of Pentamethylchromanol (PMCol)
The objective of this study is to determine the molecular mechanisms of PMCol-induced hapatotoxicity using microarray The study demonstrated that chronic exposure to high doses of PMCol induces liver damage and dysfunction, probably due to both inhibition of synthesis and depletion of liver glutathi...
ORGANISM(S): Rattus norvegicus 
2011-11-01 | E-GEOD-29673 | biostudies-arrayexpress
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