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ProteomicsACBD6-related progressive neurodevelopmental disorder – whole proteome of developing Xenopus tropicalis
In quadruplicate for each condition, 10 acbd6 WT, 68 acbd6 crispant and 71 crispant X. tropicalis embryos were incubated with 20 μM YnMyr for 17 h. After labelling, embryos were washed twice with fresh 0.05 x MMR, flash frozen in liquid nitrogen and stored at -80°C until further analysis.
ORGANISM(S): Xenopus tropicalis 
2024-06-16 | PXD043680 | Pride
Acbd6 Xenopus tropicalis Whole proteome 
ProteomicsACBD6-related progressive neurodevelopmental disorder – chemical proteomics of YnMyr-labelled proteins in developing Xenopus tropicalis
In quadruplicate for each condition, 10 acbd6 WT, 68 acbd6 crispant and 71 crispant X. tropicalis embryos were incubated with 20 μM YnMyr for 17 h. After labelling, embryos were washed twice with fresh 0.05 x MMR, flash frozen in liquid nitrogen and stored at -80°C until further analysis.
ORGANISM(S): Xenopus tropicalis 
2024-06-16 | PXD043677 | Pride
Acbd6 Xenopus tropicalis N-myristoylation Ynmyr 
ProteomicsBi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive complex movement disorders
The acyl-CoA-binding domain-containing protein 6 (ACBD6) is ubiquitously expressed, plays a role in the acylation of lipids and proteins, and regulates the N-myristoylation of proteins via N-myristoyltransferase enzymes (NMTs). However, its precise function in cells is still unclear, as is the conse...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD024957 | Pride
N-myristoylation Metabolic tagging Myristic acid alkyne ynmyr Chemical proteomics Imp-1088 Acbd6 
ProteomicsACBD6-related progressive neurodevelopmental disorder – whole proteome of developing Danio rerio (zebrafish)
In triplicate for each condition, 12 WT and acbd6 F0 crispant Danio rerio (zebrafish) embryos were incubated with 20 μM YnMyr for 24 h, either between 48-72 hpf or 96-120 hpf. After labelling, zebrafish were washed twice with fresh egg water, deyolked, flash frozen in liquid nitrogen and stored at -...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-06-16 | PXD043679 | Pride
Acbd6 Whole proteome Danio rerio 
ProteomicsACBD6-related progressive neurodevelopmental disorder – chemical proteomics of YnMyr-labelled proteins in developing Danio rerio (zebrafish)
In triplicate for each condition, 12 WT and acbd6 F0 crispant Danio rerio (zebrafish) embryos were incubated with 20 μM YnMyr for 24 h, either between 48-72 hpf or 96-120 hpf. After labelling, zebrafish were washed twice with fresh egg water, deyolked, flash frozen in liquid nitrogen and stored at -...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-06-16 | PXD043676 | Pride
Acbd6 Danio rerio N-myristoylation Ynmyr 
UnknownLigand binding to the ACBD6 protein regulates the acyl-CoA transferase reactions in membranes.
Not available
S-EPMC4583085 | biostudies-literature
UnknownBi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders.
Not available
S-EPMC10994533 | biostudies-literature
UnknownAssociation of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA.
Not available
S-EPMC4727424 | biostudies-literature
UnknownACBD6 protein controls acyl chain availability and specificity of the N-myristoylation modification of proteins.
Not available
S-EPMC6399508 | biostudies-literature
UnknownRequirement of the acyl-CoA carrier ACBD6 in myristoylation of proteins: Activation by ligand binding and protein interaction.
Not available
S-EPMC7046191 | biostudies-literature
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