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ProteomicsValidation and invalidation of chemical probes for the human N-myristoyltransferases.
On-target, cell-active chemical probes are of fundamental importance in both chemical and cell biology, whereas the application of poorly-characterised probes often leads to invalid conclusions. Human N-myristoyltransferase (NMT) has attracted increasing interest as a target in cancer and infectious...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD012722 | Pride
N-myristoylation Imp-366 (ddd85646) Metabolic tagging Tris-dba palladium Myristic acid alkyne ynmyr Chemical proteomics Imp-1088 D-nmappd (b13) 2-hydroxymyristic acid 
UnknownStructure of Plasmodium vivaxN-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy.
Not available
S-EPMC11701927 | biostudies-literature
UnknownInhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry.
Not available
S-EPMC9584500 | biostudies-literature
ProteomicsQuantitative chemical proteomic analysis of YnMyr-tagged proteins in HeLa cells infected with RV16
Rhinovirus causes the common cold and drives exacerbation in asthma and COPD, leading to substantial morbidity and healthcare cost. The single positive strand RNA genome of this non-enveloped virus is translated into a single polyprotein that is processed by virus 3C protease to form three structura...
ORGANISM(S): Homo sapiens (Human) 
2018-05-09 | PXD005798 | Pride
Hela Rv16 Proteomics Myristoylation Nmt inhibition 
ProteomicsGlobal profiling of myristoylation in human lung cancer cells
The experimental design included Calu-1 and H460 cells subjected to four treatment groups (Myr, YnMyr, YnMyr + 10 nM IMP-1088, YnMyr + 100 nM IMP-1088), each with four biological replicates. All samples were ligated to AzDB and affinity enriched. Following digestion, all peptides were subjected to L...
ORGANISM(S): Homo Sapiens 
2026-02-21 | PXD074882 |
ProteomicsMYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition - Mitochondrial fractionation
Human N-myristoyltransferases (NMTs) catalyze N-terminal protein N myristoylation and are promising targets in cancer, with an emerging mechanistic rationale for targeted therapy. Here, we screened 245 cancer cell lines against IMP-1320, a potent NMT inhibitor (NMTi), and conduced pathway-level anal...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD056941 | Pride
N-myristoyltransferase Proteomics Mitochondrial fractionation N-myristoylation 
ProteomicsBi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive complex movement disorders
The acyl-CoA-binding domain-containing protein 6 (ACBD6) is ubiquitously expressed, plays a role in the acylation of lipids and proteins, and regulates the N-myristoylation of proteins via N-myristoyltransferase enzymes (NMTs). However, its precise function in cells is still unclear, as is the conse...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD024957 | Pride
N-myristoylation Metabolic tagging Myristic acid alkyne ynmyr Chemical proteomics Imp-1088 Acbd6 
UnknownRepurposing Drugs for Synergistic Combination Therapies to Counteract Monkeypox Virus Tecovirimat Resistance.
Not available
S-EPMC11769280 | biostudies-literature
UnknownFragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.
Not available
S-EPMC6015761 | biostudies-literature
TranscriptomicsInhibition of host N-myristoylation compromising the infectivity of SARS-CoV-2 due to Golgi-bypassing egress
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused coronavirus disease 2019 (COVID-19) pandemic, remains a global health crisis despite vaccines, neutralizing antibodies, and antiviral drugs. Emerging mutations can reduce the effectiveness of these treatments, suggesting that...
ORGANISM(S): Homo sapiens 
2025-09-29 | GSE268178 | GEO
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