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MetabolomicsRed-Fleshed Apple Anthocyanin Extracts Attenuate Male Reproductive System Dysfunction Caused by Busulfan in Mice (Apple extract; UPLC-MS/MS assay)

In this research, we analyzed the effect of oral administration of red-fleshed apple anthocyanin extract (RAAE) on busulfan-treated mice. At first, we showed that the most abundant component in RAAE was cyanidin 3-O-galactoside. To determine the effect of RAAE, mice were divided into control and ...

2021-06-07 | MTBLS2863 | MetaboLights
ProteomicsImpact of Oxygen Tension on the Proteomic Profile of hCMEC/D3 Cells and Implications for Drug Screening
Untargeted bottom-up proteomic analysis of hCMEC/D3 cells, cultured at 5 kPa and 18 kPa O₂, in the presence and absence of sulforaphane treatment, using an ACQUITY UPLC M-Class system coupled to a SYNAPT G2-Si mass spectrometer.
ORGANISM(S): Homo Sapiens (human) 
2025-04-12 | PXD060622 | JPOST Repository
ProteomicsLFQ proteomics of Streptomyces albus phosoablative CslA mutant strain
Aim of this study was to compare proteomic profiles of the WT and the pMD8 mutant strains of Streptomyces albus. pMD8 is a mutant encoding a phosphoablative form of the CslA gene (T17A). Study is a part of a bigger project on the roles of PknB and CslA proteins in cell wall morphogenesis of Streptom...
ORGANISM(S): Streptomyces albus J1074 
2026-06-17 | PXD071342 | Pride
Hdmse Tip organising centre (tipoc) Cell morphogenesis Roda Csla Lfq Phosphorylation Streptomyces Pknb Polarisome Cell wall Bottom-up 
ProteomicsMechanism of chaperone coordination during cotranslational protein folding in bacteria
Protein folding is assisted by molecular chaperones that bind nascent polypeptides during mRNA translation. Several structurally-distinct classes of chaperones promote de novo folding, suggesting that their activity is coordinated at the ribosome. Here we use biochemical reconstitution and structura...
ORGANISM(S): Escherichia coli 
2024-07-03 | PXD048638 | Pride
Nascent chain Ribosomes Hdx-ms Molecular chaperones Protein synthesis Β-galactosidase Protein folding 
MetabolomicsMetabolic alterations in immune cells associate with progression to type 1 diabetes

AIMS: Previous metabolomics studies suggest that type 1 diabetes is preceded by specific metabolic disturbances. The aim of this study was to investigate whether distinct metabolic patterns occur in peripheral blood mononuclear cells (PBMCs) of children who later develop pancreat...

2020-08-10 | MTBLS1015 | MetaboLights
MetabolomicsTemporal multi-omics dataset of a cucurbit–powdery mildew interaction

This study presents a time-resolved untargeted LC–MS/MS metabolomics dataset of the interaction between melon (Cucumis melo) and the obligate biotrophic fungus Podosphaera xanthii, the causal agent of cucurbit powdery mildew. Mock-treated and inoculated plants were sampled every 12 hours from 12 ...

2026-09-24 | MTBLS15447 | MetaboLights
ProteomicsRAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues, cancer cells, and macrophages - label-free MS RAPIDASH of E12.5 mouse forebrain
Ribosomes are emerging as direct regulators of gene expression, with ribosome-associated proteins (RAPs) allowing ribosomes to modulate translation. Nevertheless, a lack of technologies to enrich RAPs across sample types has prevented systematic analysis of RAP identities, dynamics, and functions. W...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-22 | PXD054303 | Pride
Acquity uplc m-class system Embryo Orbitrap elite Forebrain Ribosome Ribosome-associated proteins Mouse 
MetabolomicsMetabolic plasticity of lipid storage and utilization governs fungal persister formation within macrophages
The ability of Candida glabrata to survive within macrophages creates a reservoir for recurrent infections and antifungal failure, yet the underlying mechanisms remain elusive. Here, using a host-mimicking in vitro evolution model, we identify asparagine synthetase (ASN2) as a critical genetic deter...
2026-04-22 | MTBLS14351 | MetaboLights
ProteomicsRAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues, cancer cells, and macrophages - TMT MS RAPIDASH comparison with original chromatographic purification of yeast ribosomes (Meskauskas, et al. 2011)
Ribosomes are emerging as direct regulators of gene expression, with ribosome-associated proteins (RAPs) allowing ribosomes to modulate translation. Nevertheless, a lack of technologies to enrich RAPs across sample types has prevented systematic analysis of RAP identities, dynamics, and functions. W...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-12 | PXD054427 | Pride
Acquity uplc m-class system Orbitrap elite Chromatography Ribosome Tmt ms Ribosome-associated proteins Mouse 
MetabolomicsRelationship Between Vitamin D Levels and Psychological Stress-Induced Asthma Prevalence: An Untargeted Metabolomics Study Combined with the NHANES Database
The incidence of psychological stress–induced asthma has been increasing annually, and numerous previous studies have shown that vitamin D is associated with the development of asthma as well as anxiety and depression. However, no studies to date have clarified the relationship between vitamin D and...
2026-04-16 | MTBLS14208 | MetaboLights
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