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TranscriptomicsMechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis
Data from clinical studies, cell culture, and animal models implicate the urokinase (uPA)/Plasminogen (Plg) system in the development of atherosclerosis and aneurysms. However, the mechanisms through which uPA/Plg stimulate these diseases are not yet defined. We used genetically modified, atherosc...
ORGANISM(S): Mus musculus 
2011-05-03 | E-GEOD-29028 | biostudies-arrayexpress
TranscriptomicsAge and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Recombinant tissue-type plasminogen activator (tPA) is the fibrinolytic drug of choice to treat stroke patients. However, a growing body of evidence indicates that besides its beneficial thrombolytic role, tPA can also have a deleterious effect on the ischaemic brain. Although ageing influences stro...
ORGANISM(S): Mus musculus 
2009-08-23 | E-GEOD-9004 | biostudies-arrayexpress
TranscriptomicsThe kinase TNIK is an essential activator of Wnt target genes
Wnt signalling maintains the undifferentiated state of intestinal crypt/progenitor cells through the TCF4/ß-catenin activating transcriptional complex. In colorectal cancer, activating mutations in Wnt pathway components lead to inappropriate activation of the TCF4/ß-catenin transcriptional progra...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-17623 | biostudies-arrayexpress
TranscriptomicsEH004: Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/b-catenin signaling activator Rspo2
Recent developments in molecular programming of mesodiencephalic dopaminergic (mdDA) neurons have led to the identification of many transcription factors playing a role in mdDA specification. LIM homeodomain transcription factor Lmx1a is essential for chick mdDA development, and for the efficient di...
ORGANISM(S): Mus musculus 
2013-12-13 | E-GEOD-45831 | biostudies-arrayexpress
GenomicsIncrease genome editing efficiency by Cas9 transcriptional activator and histone acetyltransferase activator
Increase genome editing efficiency by Cas9 transcriptional activator and histone acetyltransferase activator
PRJNA827683 | ENA
ProteomicsHDXMS of urokinase plasminogen activator
HDX-MS of urokinase plasminogen activator in single-chain vs two-chain forms
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-28 | MSV000090611 | MassIVE
ProteomicsSts2, a transcriptional activator effector of Ustilago maydis, regulates hyperplasia in maize during pathogen-induced tumor formation
Ustilago maydis causes common smut in maize, which is characterized by tumor formation in aerial parts of maize. Tumor comes from the de novo cell division of highly developed bundle sheath and subsequent cell enlargement. However, its mechanism is still unknown. Here, we characterize the U. maydis ...
ORGANISM(S): Zea mays (Maize) 
2023-10-12 | PXD040350 | Pride
Ustilago maydis Bundle sheath Transcriptional activator Hyperplasia tumor Leaf developmental regulator 
TranscriptomicsInnate response activator B cells are sentinels that guard against polymicrobial sepsis
Innate immunity is fundamental to recognition and clearance of bacterial infection. The relevant cells and molecules that orchestrate an effective response, however, remain incompletely understood. Here we describe a previously unknown population of B cells, which we have named innate response activ...
ORGANISM(S): Mus musculus 
2012-02-07 | E-GEOD-32372 | biostudies-arrayexpress
ProteomicsStructure of Saccharomyces cerevisiae Mediator-RNA polymerase II pre-initiation complex for divergent transcription
This study has determined structure of transcription initiation complexes including a DNA-bound activator, RNA polymerase II (Pol II), and Mediator on a divergent promoter GAL80/SUT719 using a combination of cryo-EM and XL-MS analyses. Our cryo-EM single-particle analysis reveals a dimeric form of ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-05-22 | PXD036149 | Pride
Enhancer Divergent transcription Transcription Mediator Uas Initiation Activator Rna polymerase ii 
ProteomicsAMPK activator 991 specifically activates SnRK1 and thereby affects seed germination in rice
Sucrose non-fermenting-1-related protein kinase 1 (SnRK1) is a central regulator of metabolism and developmental transition in plant. Compound 991 is a well-known 5′-adenosine monophosphate activated protein kinase (AMPK) activator in mammals. SnRK1 and AMPK are highly conserved. However, whether 99...
ORGANISM(S): Oryza sativa (Rice) 
2024-02-04 | PXD044360 | Pride
Rice Snrk1 Ampk activator Germination Phosphoproteomics 
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