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TranscriptomicsSystematic Mapping of ADAR1 Binding Reveals its Regulatory Roles in Multiple RNA Processing Pathways [small RNA-seq]
ADARs are the primary factors underlying A-to-I editing in metazoans. We conducted the first global study of ADAR1-RNA interaction in human cells using CLIP-Seq. In contrast to the expected predominant binding of ADAR1 to Alu repeats, thousands of CLIP sites were located in non-Alu regions. This une...
ORGANISM(S): Homo sapiens 
2015-03-11 | E-GEOD-55362 | biostudies-arrayexpress
TranscriptomicsADAR1-mediated A-to-I RNA editing is essential for erythropoiesis [RNA-seq]
Purpose: RNA editing by ADAR1 is essential for hematopoietic development. The goals of this study were firstly, to identify ADAR1-specific RNA-editing sites by indentifying A-to-I (G) RNA editing sites in wild type mice that were not edited or reduced in editing frequency in ADAR1 deficient murine e...
ORGANISM(S): Mus musculus 
2016-07-24 | E-GEOD-71042 | biostudies-arrayexpress
TranscriptomicsThe RNA editing enzyme ADAR1 is a key regulatory of innate immune responses to RNA
The ADAR RNA editing enzymes deaminate adenosine bases to inosines in cellular RNAs, recoding open reading frames. Human ADAR1 mutations cause Aicardi-Goutieres Syndrome (AGS) and Adar1 mutant mice showing an aberrant interferon response and death by embryonic day E12.5 model the human disease. Sear...
ORGANISM(S): Mus musculus 
2014-12-19 | E-GEOD-62917 | biostudies-arrayexpress
ProteomicsRole of ADAR1 in human macrophages
This study aims to delineate the role of ADAR1 in human cells beyond its canonical function as an interferon-stimulated gene (ISG). Human monocyte-derived macrophages were subjected to RNA interference targeting either pan-ADAR1 (both isoforms) or the p150 isoform specifically. Quantitative proteomi...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD073582 | Pride
Macrophages Human Adar1 
TranscriptomicsADAR1 regulates melanoma progression via miRNAs biogenesis
Aberrant RNA-editing was observed in several human tumors, but its significance is mostly unknown. Here we show that ADAR1, a ubiquitous RNA-editing enzyme, is commonly lost in metastatic melanoma cells and specimens. Experimental ADAR1 silencing significantly alters melanoma cell morphology, facili...
ORGANISM(S): Homo sapiens 
2012-08-31 | E-GEOD-31963 | biostudies-arrayexpress
ProteomicsThe effect of ADAR1 depletion on mitochondrial proteins
In this study, we found that ADAR1 reduces the levels of double-stranded RNAs (dsRNAs) derived from both nuclear and mitochondrial transcripts. To elucidate how ADAR1 controls mitochondrial dsRNA (mt-dsRNA) accumulation, we performed quantitative mass spectrometry on mitochondrial protein fractions ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD069896 | Pride
ProteomicsIdentification of ADAR1 associated proteins
To understand how ADAR1 controls genome stability, affinity purification and mass spectrometry were employed to identify the interactomes of ADAR1 with cellular extracts from HeLa cells stably expressing FLAG-ADAR1.Mass spectrometry analysis of FLAG-ADAR1 associated proteins. The differential protei...
ORGANISM(S): Homo Sapiens 
2022-11-15 | PXD038167 |
TranscriptomicsRNA editing by ADAR1 is essential for erythropoiesis [array]
Erythroid progenitors purified from EpoRCreR26eYFPADAR1fl/- and EpoRCreR26eYFPADAR1fl/+ control mice were compared for global gene array profiles Each sample was purified from one mouse
ORGANISM(S): Mus musculus 
2016-07-24 | E-GEOD-59664 | biostudies-arrayexpress
TranscriptomicsADAR1-mediated A-to-I RNA editing is essential for erythropoiesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-07-24 | E-GEOD-71047 | biostudies-arrayexpress
TranscriptomicsHematopoietic stem cell (HSC) expression alteration in an ADAR1 mouse model
Hematopoietic stem cells purified from +/+, +/- and -/- ADAR1 mice were compared with global gene expression analysis. Each sample was purified from one mouse.
ORGANISM(S): Mus musculus 
2008-12-07 | E-GEOD-12772 | biostudies-arrayexpress
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