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MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
GenomicsSingle-cell sequencing of adipose-derived mesenchymal stromal cells and dermal fibroblasts
Single-cell sequencing of adipose-derived mesenchymal stromal cells and fibroblasts.
EGAS00001006954 | EGA
TranscriptomicsRNA-Seq Analysis Reveals Different Dynamics of Differentiation of Human Dermis- and Adipose-derived Stromal Stem Cells
Background: Tissue regeneration and recovery in the adult body depends on self-renewal and differentiation of stem and progenitor cells. Mesenchymal stem cells (MSCs) that have the ability to differentiate into various cell types, have been isolated from the stromal fraction of virtually all t...
ORGANISM(S): Homo sapiens 
2012-06-27 | E-GEOD-37521 | biostudies-arrayexpress
TranscriptomicsExpression data of human perirenal adipose tissue-derived mesenchymal stem cells cultured under various conditions
Human mesenchymal stem cells (MSC) derived from perirenal adipose tissue (PV) of living kidney donors were cultured under various conditions, namely (1) control (medium+foetal bovine serum(FBS)) or (2) control (medium+heat-inactivated FBS); (3) with mixed-lympohocyte reactions (MLR) in transwell cul...
ORGANISM(S): Homo sapiens 
2010-10-01 | E-GEOD-18662 | biostudies-arrayexpress
ProteomicsMulti-omics approach to identify age-related changes in mesenchymal stem cells
Mesenchymal stem cells (MSC) are bone-marrow derived cells, capable of multipotent differentiation into connective tissues including bone, tendon and cartilage. They are an attractive source for autologous cell-based treatments for a range of clinical diseases and injuries. MSCs have been demonstra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079981 | MassIVE
ProteomicsProteome characterization of mesenchymal stem cells and exosomes
Proteome characterization of mesenchymal stem cells (MSC) and exosomes. MSCs were cultured in normoxic, hypoxic and in presence of FBS. Exosomes were prepared from normoxic and hypoxic conditions.
ORGANISM(S): Homo Sapiens (human) 
2021-04-27 | PXD025584 | JPOST Repository
ProteomicsComprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers
Mesenchymal stem cells (MSC) are multipotent cells with great potential in therapy, reflected by more than 500 MSC-based clinical trials registered with the NIH. MSC are derived from multiple tissues but require invasive harvesting and imply donor-to-donor variability. Embryonic stem cell-derived MS...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080827 | MassIVE
ProteomicsAge-related changes in the proteome and mitochondrial metabolism of rabbit adipose-derived stromal/stem cells
In this study, the proteome and metabolic properties of primary subcutaneous (s) and visceral (v) adipose tissue-derived stromal stem cells (ASC) from old and young rabbits were analysed by a mass spectrometry-based label-free quantification approach and combined with metabolic mitochondrial respira...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2025-01-19 | PXD057467 | Pride
Stem cell ageing Mitochondrial metabolism Rabbit Adipose-derived stromal stem cells 
ProteomicsMesenchymal stem cell integrin-associated complexes
The composition and stiffness of the extracellular matrix (ECM) environment that surrounds Multipotent mesenchymal stem cells (MSCs) stem cells dictates transcriptional programming, thereby affecting stem cell lineage decision-making. Cells sense force between themselves and their microenvironment ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079956 | MassIVE
ProteomicsProteomic dataset of exosomes derived from fetal mesenchymal stromal cells
The raw files of the proteomics dataset are N=18 and a brief description of the files is shown below: AF1 raw: exosomes derived from Amniotic Fluid-Mesenchymal Stromal cells 1 AF2.raw: exosomes derived from Amniotic Fluid-Mesenchymal Stromal cells 2 AFA1.raw: exosomes derived from Amniotic Fl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092848 | MassIVE
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