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ProteomicsAngiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells
Glioblastoma multiforme (GBM) is an aggressive, heterogeneous and highly vascularized brain tumor. GBM is thought to arise from glioblastoma stem-like cells (GSCs) which are characterized as being either proneural or mesenchymal. The former isolates of GSCs are tight sphere forming and slow growing ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD034819 | Pride
Glioblastoma stem cells Endothelial cells Extracellular vesicles Glioblastoma Heterogeneity Mesenchymal Invasion Migration Proneural 
ProteomicsImmune cell infiltration into brain tumor microenvironment is mediated by Rab27-regulated vascular wall integrity
Aggressive brain tumors often exhibit immunologically ‘cold’ microenvironment, where the vascular barrier impedes effective immunotherapy in poorly understood ways. Tumor vasculature also plays a pivotal role in immunoregulation and antitumor immunity. Here we show that small GTPase Rab27 controls t...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-02 | PXD062939 | Pride
Brain tumor Adoptive immunity Cytotoxic t-cells Glioma Vasculature Blood brain barrier Endothelial cells Tight junctions. Tumor microenvironment 
UnknownEffect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data.
Not available
S-EPMC12701713 | biostudies-literature
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