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ProteomicsAngiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells
Glioblastoma multiforme (GBM) is an aggressive, heterogeneous and highly vascularized brain tumor. GBM is thought to arise from glioblastoma stem-like cells (GSCs) which are characterized as being either proneural or mesenchymal. The former isolates of GSCs are tight sphere forming and slow growing ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD034819 | Pride
Glioblastoma stem cells Endothelial cells Extracellular vesicles Glioblastoma Heterogeneity Mesenchymal Invasion Migration Proneural 
TranscriptomicsPDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-mediated Survival of Proneural Glioma Cells.
Identification of critical survival determinants of PDGF-driven proneural glioma. Results provided information about the genes and pathways that are regulated by PDGF signaling in PDGF-driven proneural glioma and led to the assessment of the importance of the USP1-ID2 axis in proneural glioma. Total...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-77423 | biostudies-arrayexpress
TranscriptomicsPDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-mediated Survival of Proneural Glioma Cells.
Identification of critical survival determinants of PDGF-driven proneural glioma. Results provided information about the genes and pathways that are regulated by PDGF signaling in PDGF-driven proneural glioma and led to the assessment of the importance of the USP1-ID2 axis in proneural glioma. Total...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-77419 | biostudies-arrayexpress
TranscriptomicsThe gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons
A challenge in systems biology is to understand the gene regulatory networks that connect early cellular specification to terminal differentiation of specific cell types. In neurogenesis, neural specification has been well studied, but the link between the proneural transcriptional regulators of spe...
ORGANISM(S): Drosophila melanogaster 
2011-02-18 | E-GEOD-21520 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila FACS sorted cells derived from imaginal discs to identify genes preferentially expressed in proneural cluster cells
Fluorescence-activated cell sorting of M4-GFP wing imaginal disc cells was used to recover a purified population of the cells that comprise the proneural clusters from which sensory organ precursors of the peripheral nervous system (PNS) arise. Whole-genome microarray analysis and in situ hybridizat...
ORGANISM(S): Drosophila melanogaster 
2007-07-07 | E-GEOD-2359 | biostudies-arrayexpress
TranscriptomicsPatients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial
The AVAglio and RTOG-0825 randomized, placebo-controlled phase III trials in newly diagnosed glioblastoma reported prolonged progression-free survival (PFS), but not overall survival (OS), with the addition of bevacizumab to radiotherapy/temozolomide. To establish whether certain patient subgroups d...
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-84010 | biostudies-arrayexpress
TranscriptomicsCross-Species Comparison Identifies Proneural specific patterns of genetic alterations in Glioblastoma
The determinants of the genetic complexity of Glioblastoma are poorly understood. We generated murine Glioblastomas by transforming glial progenitors in the adult brain with PDGF expression and PTEN deletion +/- p53 deletion. PDGF+PTEN-/- tumors developed additional deletions of specific genes in up...
ORGANISM(S): Mus musculus 
2014-01-17 | E-GEOD-36940 | biostudies-arrayexpress
GenomicsGene expression profile of murine proneural glioblastoma
Gene expression profile of murine proneural glioblastoma
PRJNA716179 | ENA
GenomicsClemastine suppresses proneural glioblastoma stem cell growth
Clemastine suppresses proneural glioblastoma stem cell growth
PRJNA773389 | ENA
GenomicsClemastine suppresses proneural glioblastoma stem cell growth II
Clemastine suppresses proneural glioblastoma stem cell growth II
PRJNA773719 | ENA
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